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Steroid Mouthwash for Oral Mucositis
Steroid mouthwash for oral mucositis can be a safe and effective therapy, according to the study below. For multiple myeloma patients about to undergo an ASCT, should give serious consideration to the content below.
In my experience as a MM survivor and MM cancer coach, oral mucositis is very common for those MM patients undergoing an autologous stem cell transplant. Steroid mouthwash sounds like a gread combination of efficacy and ease of use.
Oral Mucositis | Managing Oncology Treatment Side Effects
Email me at David.PeopleBeatingCancer@gmail.com to learn more about both conventional and non-conventional MM therapies.
Good luck,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Efficacy and Safety of Topical Steroid Therapy for Oral Mucositis During Cancer Chemotherapy: A Scoping Review
“Abstract
Oral mucositis (OM) is a common and debilitating complication of cancer chemotherapy and targeted therapies, significantly affecting patients’ quality of life and potentially leading to treatment delays or dose reductions.
Although topical corticosteroids have demonstrated anti-inflammatory effects, their clinical use for OM remains limited, particularly in countries such as Japan, due to regulatory and safety concerns.
This scoping review examined existing evidence on the efficacy and safety of topical corticosteroid therapy-administered via mouthwash or ointment, for the prevention and management of OM in patients undergoing cancer pharmacotherapy.
A comprehensive literature search was conducted using PubMed and Scopus to identify English-language studies published up to June 2025, and six eligible studies were included in the qualitative synthesis. The reviewed studies demonstrated that topical corticosteroid therapy, particularly dexamethasone-based mouthwashes and ointments, was associated with significant reductions in OM incidence and severity, with no adverse events such as oral candidiasis reported.
Randomized controlled trials by Niikura et al. and Kuba et al. provided the most robust evidence, supporting both efficacy and safety. Moreover, combined use with professional oral care may further enhance therapeutic outcomes. Overall, topical corticosteroids appear to be a safe and effective intervention for managing chemotherapy- and targeted therapy-induced OM.
However, the evidence remains limited by small sample sizes and heterogeneous study designs, underscoring the need for large-scale clinical trials to standardize treatment protocols, evaluate long-term safety, and inform future guidelines and policy development…
Findings
Topical steroid therapy, whether via mouthwash or ointment, appears to be a promising approach for both prevention and management of chemotherapy- or targeted therapy-induced OM. Several previous studies, including the SWISH trial and RCTs by Niikura et al. and Kuba et al., have demonstrated the efficacy of topical corticosteroids in reducing OM incidence and severity…
Conclusions
This scoping review highlights the potential of topical corticosteroid therapy, administered via mouthwash or ointment, as a safe and effective strategy for the prevention and management of OM in patients undergoing cancer chemotherapy or targeted therapy. The reviewed studies, including randomized controlled trials, consistently reported reductions in the incidence and severity of OM without significant adverse effects such as oral candidiasis. When combined with professional oral care, topical steroids may provide a valuable addition to current supportive care protocols.”
Steroid mouthwash for oral mucositis Steroid mouthwash for oral mucositis