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Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.

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The COC Protocol for Myeloma?

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Hi David- I have a question I hope you could help with.  I have had a course of chemo in 2022 with Velcade, Dexamethasone, Thalidomide, I am sorry I cannot remember the 4th drug.  They stopped the Velcade (Bortizomib) due to it causing heart problems.

I recently bought mebendazole and I have prescription for atorvastatin but have never filled it.
My question is, seeing that my other results are good (although proteins steadily climbing) I wonder if it is worth jumping into chemo, although they insist I should start.  I live in the UK so there is no financial advantage for them to want to start (unless they are getting kickbacks).
There is a clinic in London called Care Oncology Centre, which is expensive for me, but it uses the Mebendozole, Metformin, Atorvastatin, Doxycycline protocol.  aka the COC Protocol for myeloma. I wonder if this is worth pursing.  I am just so scared, I am only 60, and frightened of this chemo killing me yet I feel if I do nothing it will kill me.
I currently take curcumin C3 8g a day, resveratrol, and a host of others. Let me know what you think. Julie

Hi Julie-
My guess is that the fourth chemo in your induction therapy was darzelex aka daratumumab. This induction cocktail is standard, You are correct, Velcade has been shown to cause heart damage aka it is cardiotoxic. Unfortunately, Carfilzomib is also cardiotoxic. Your oncologists should know this.
If I understand your question, you are saying that your current M-spike is 12? I think your unit of measurement compared to the U.S.’s means that your m-pspike is 1.2. And you say that your m-spike at diagnosis was 34 aka 3.4?
My thinking is that your induction therapy put you into remission. Perhaps not “complete remission” but depending on your other numbers at diagnosis, you became stable. You are coming out of remission and the next decision you face is when to continue treatment?
Oncology tents to treat MM aggressively. I think they do this because of, as you pointed out, incentives and also because the less advance the MM is, the easier it is to treat. As you’ve seen however, your MM was more advanced when you were first diagnosed and you then reached remission so…
Your options, as I see them, are four-
  1.  Follow your oncologist’s recommendations-
  2.  Take a therapy vacation aka no chemo for a time- the length of that time depends on you, your diagnostic goals.
  3.  Follow a therapy plan in between 1 and 2- not full chemo (1) and not no chemo (2). Perhaps low dose maintenance therapy.
  4. Undergo the other therapies that you mention. I know little about the Mebendozole, Metformin, Atorvastatin, Doxycycline protocol. This is referred to as the COC Protocol. I would have to research this protocol and its possible effect, if any, on multiple myeloma.
I understand your fear, and dislike of toxicity. I share both feelings. I can give you a clearer picture and choices but I will have to study your diagnostic info more thoroughly. It is premature for me to say much but because conventional therapies cannot cure MM, I should research the COC Protocol for myeloma more thoroughly. 
Also, please undergo the anti-MM therapies that you read about in the MM CC Course.
I don’t know if this all will help you. Let me know if you have any questions.
David Emerson

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