Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission
Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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“Our study suggests that EPA and DHA induce selective cytotoxic effects in MM and increase sensitivity to bortezomib (velcade)…Combined curcumin and PS-341 treatment has been reported to enhance cytotoxicity and minimize adverse effects…”
Dear Cancer Coach- I was diagnosed with multiple myeloma (MM) in march 2018 with 20% infiltrate pp 8.1 L/C 240 . LH Went up slowly to 480 consultant decided to start chemo of V/C/D. I have been taking CBD OIL, as an integrative therapy, since being diagnosed. I’m am now taking cannabis oil with THC.
First set of results looked very promising PP 4 L/C 170 second set PP3 LC240 which was disappointing haven’t had many side-effects apart form insomnia from the Dex .
Was taking omega 3, 2,000 mg daily and Turmeric/Curcumin 1200 mg daily, also as integrative therapies, then I started treatment. I stopped because was I was worried the supplementation might somehow stop the chemo working.
I just wondered what your thoughts were. I’m 52, fit and heathy, otherwise never had any side-effects its the mental side thats difficult for me.
Any advice you have would be very much appreciated. Thanks for sharing your time. Regards Peter
Dear Peter,
I am sorry to read of your MM diagnosis though it sounds as though you are doing well. I will break down your questions/comments below with questions and comments of my own.
1) Myeloma terminology in your country may be different than it is here. Does “20% infiltrate” mean that your bone marrow was 20% MM cells upon diagnosis? That MM had infiltrated your bone marrow by 20%?
2) “pp 8.1” I can’t figure out what this means.
3) “L/C 240” Are you referring to your light chains?
4) “ LH Went up slowly to 480” liters per hour increased to 480?
5) “I have been taking CBD OIL since being diagnosed.” CBD oil enhances Velcade, and is anti-angiogenic. AKA, CBD oil is an integrative therapy for MM.
6) “I’m am now talking cannabis oil with THC . First set of results looked very promising PP 4 L/C 170 second set PP3 LC240 which was disappointing”
CBD and MM research is limited. The percentage of THC with cannabinoids had not been determined where MM is concerned.
7) “haven’t had many side effects apart form insomnia from the Dex” Yes, this happens to many of us. I took Dex. first thing in the am in hopes of tiring by days end. Also, if insomnia is too much of a problem, reduce the daily dose of Dex.
8) “Was taking omega 3.. 2,000 mg daily and Turmeric 1200mg daily then it started treatment i stopped because was worried it might somehow stop the chemo working. I just wondered what your thoughts were.”
Omega-3 fatty acids and curcumin both, repeatedly, have been shown to enhance the efficacy of chemo while also being cytotoxic to MM. See the linked studies below.
9) “I’m 52, fit and heathy otherwise. I’ve never had any physical side-effects. Its the mental side-effects that are difficult for me. Any advice would be very much appreciated .thanks for sharing your time. Regards Peter”
52 is young as MMers go. Young, fit and healthy puts you well ahead of the averages. Daily, moderate exercise is a valuable MM therapy in its own right. Overall, your MM appears to be diagnosed when it was relatively early. Combining non-conventional with moderate conventional therapies, in my experience, is the best way to insure a high quality of life with a long quantity of life.
The mental side is difficult for all of us. I will attach the MM CC mind-body guide. I practice many of the m-b therapies myself and have for years…
I will address issues 1-4 if you can clarify the meanings…thanks
Let me know if you have any other questions.
Hang in there,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Recommended Reading:
Curcumin Enhances Cytotoxic Effects of Bortezomib in Human Multiple Myeloma H929 Cells: Potential Roles of NF-κB/JNK
“Combined curcumin and PS-341 treatment has been reported to enhance cytotoxicity and minimize adverse effects through ERK and p38MAPK mechanisms in human multiple myeloma cells…”
Omega-3 fatty acids, EPA and DHA induce apoptosis and enhance drug sensitivity in multiple myeloma cells but not in normal peripheral mononuclear cells.
” Our study suggests that EPA and DHA induce selective cytotoxic effects in MM and increase sensitivity to bortezomib and calls for further exploration into a potential application of these n-3 polyunsaturated fatty acids in the therapy of MM….”
The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2.
“Multiple myeloma (MM) is a plasma cell (PC) malignancy characterised by the accumulation of a monoclonal PC population in the bone marrow (BM).
Cannabidiol (CBD) is a non-psychoactive cannabinoid with antitumoural activities, and the transient receptor potential vanilloid type-2 (TRPV2) channel has been reported as a potential CBD receptor.
TRPV2 activation by CBD decreases proliferation and increases susceptibility to drug-induced cell death in human cancer cells. However, no functional role has been ascribed to CBD and TRPV2 in MM.
In this study, we identified the presence of heterogeneous CD138+TRPV2+ and CD138+TRPV2- PC populations in MM patients, whereas only the CD138+ TRPV2- population was present in RPMI8226 and U266 MM cell lines.
Because bortezomib (BORT) is commonly used in MM treatment, we investigated the effects of CBD and BORT in CD138+TRPV2- MM cells and in MM cell lines transfected with TRPV2 (CD138+TRPV2+).
These results showed that CBD by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death by regulating the ERK, AKT and NF-κB pathways with major effects in TRPV2+ cells.
These data provide a rationale for using CBD to increase the activity of proteasome inhibitors in MM.”