When I read the studies linked and excerpted below I thought I was reading a study about vitamin D3 supplementation and cancer risk. Numerous studies cite low vitamin D3 blood levels as increasing the risk of many cancers. I was actually reading about the risk of dementia and Alzheimer’s disease.
If you are genetically predisposed to Alzheimer’s disease or if you have been diagnosed with early Alzheimer’s then you may be interested in learning more about what the study below means to you.
First and foremost, when the study says “low vitamin D concentrations,” the authors are talking about concentrations in your blood aka serum blood levels. The only way to check this is through blood testing. I check my serum/blood levels through LabCorp. You can email me below if you would like to know more.
I take 3000 mg daily (1000 mg x 3) and my last blood test indicated that my serum level was 31. Keep in mind that I live in Northeastern Ohio and I stay out of the sun as much as I can.
The bottom line is that low blood levels of vitamin D3 increase your risk of many chronic diseases including Alzheimer’s disease. Vitamin D3 supplementation will reduce your risk of Alzheimer’s disease and be supplementing with vitamin D3 may slow the progress of Alzheimer’s if you have already been diagnosed with it.
I supplement with Life Extension Vitamin D3- 1000 mg x 3 daily. I take this brand because it has been tested and approved by Consumerlab.com.
For more information about nutritional supplementation and Alzheimer’s Disease, scroll down the page, post a question or comment and I will reply ASAP.
“METHODS: We performed a systematic search of PubMed and Scopus from database inception up to September 2017. Longitudinal cohort studies reporting risk estimates of incident dementia or AD in the general population, and for three or more quantitative categories of serum 25(OH)D were included. Pooled hazard ratios (HRs) were calculated using fixed-effects/random-effects models.
RESULTS: Seven prospective cohort studies and one retrospective cohort study (total n = 28,354) involving 1953 cases of dementia and 1607 cases of AD were included. The pooled HRs of dementia and AD were 1.09 (95%CI: 0.95, 1.24) and 1.19 (95%CI: 0.96, 1.41) for vitamin D insufficiency (10-20 ng/ml), and 1.33 (95%CI: 1.08, 1.58) and 1.31 (95%CI: 0.98, 1.65) for deficiency (<10 ng/ml), respectively. The lower risk of dementia was observed at serum 25(OH)D of ∼25 ng/ml, whereas the risk of AD decreased continuously along with the increase of serum 25(OH)D up to ∼35 ng/ml.
CONCLUSION: Higher levels of serum 25(OH)D was associated with a lower risk of dementia and AD, but we have no conclusive evidence regarding serum 25(OH)D levels of >35 ng/ml.
“OBJECTIVE: To determine whether low vitamin D concentrations are associated with an increased risk of incident all-cause dementia and Alzheimer disease…
RESULTS: During a mean follow-up of 5.6 years, 171 participants developed all-cause dementia, including 102 cases of Alzheimer disease.,,,for incident all-cause dementia in participants who were severely 25(OH)D deficient (<25 nmol/L) deficient (≥25 to <50 nmol/L) were 2.25 and 1.53 compared to participants with sufficient concentrations (≥50 nmol/L).
The multivariate-adjusted hazard ratios for incident Alzheimer disease in participants who were severely 25(OH)D deficient and deficient compared to participants with sufficient concentrations were 2.22…
…the risk of all-cause dementia and Alzheimer disease markedly increased below a threshold of 50 nmol/L.
CONCLUSION: Our results confirm that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease. This adds to the ongoing debate about the role of vitamin D in nonskeletal conditions.”