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Vitamin D- Obesity-Induced Increase in Endometrial Cancer-

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“Our data confirm the known association between obesity and endometrial cancer risk. Dietary exposure to VD3 inhibited the carcinogenic effect of obesity on the endometrium.”

Obesity increases the risk of cancer, endometrial cancer in particular. According to the first study linked and excerpted below, oncology doesn’t understand why. In general I think it is safe to say that obesity increases inflammation in people and increased inflammation increases the risk of cancer.
While there are many evidence-based, non-toxic therapies shown to reduce the risk of various cancers including nutrition, exercise, detox, and others, one way to reduce your risk of endometrial cancer, according to the second and third studies linked below, is to supplement with either/or/both curcumn and vitamin D3 (VD3).
Vitamin D has been shown to enhance bone health while reducing the risk of many different types of cancer, including endometrial cancer. I have taken Life Extension Vitamin D3 daily (1000 mg. x 3 w/ food) for more than 10 years now. I take Life Extension Super BioCurcumin (400 mg) as well. Life Extension Foundation supplements have been evaluated and approved by Consumerlab.com, an independant testing company.
Have you been diagnosed with endometrial cancer? If so, what stage? Whay symptoms are you experiencing? To learn more about evidence-based, non-toxic therapies scroll down the page, post a question or comment and I will reply to you ASAP.
Thank you,
 David Emerson
  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Obesity and endometrial cancer survival: a systematic review

“Although it is known that obesity increases the risk of endometrial cancer and is linked to higher mortality rates in the general population, the association between obesity and mortality among endometrial cancer survivors is unclear.

We performed a medline search using exploded Mesh keywords ‘endometrial neoplasms/’ and (‘body mass index/’ or ‘obesity/’) and (‘survival analysis/’ or ‘mortality/’ or (survivor* or survival*).mp.). We also inspected bibliographies of relevant papers to identify related publications.

Our search criteria yielded 74 studies, 12 of which met inclusion criteria. Four of the included studies reported a statistically or marginally significant association between obesity and higher all cause mortality among endometrial cancer survivors after multivariate adjustment.

The suggestive association between body mass index and higher all cause mortality among women with endometrial cancer was comparable to the magnitude of association reported in prospective studies of healthy women. Of the five studies that examined progression-free survival and the two studies reporting on disease-specific mortality, none reported an association with obesity. Future studies are needed to understand disease-specific mortality, the importance of obesity-onset timing and whether mechanisms of obesity-related mortality in this population of women differ from those of the general population…”

Curcumin suppresses migration and invasion of human endometrial carcinoma cells

“Curcumin, a widely used Chinese herbal medicine, has historically been used in anti-cancer therapies. However, the anti-metastatic effect and molecular mechanism of curcumin in endometrial carcinoma (EC) are still poorly understood.

The purpose of this study was to detect the anti-metastatic effects of curcumin and the associated mechanism(s) in EC. Based on assays carried out in EC cell lines, it was observed that curcumin inhibited EC cell migration and invasion in vitro.

Furthermore, following treatment with curcumin for 24 h, there was a decrease in the expression levels of matrix metalloproteinase (MMP)-2 and -9 as well as proteinase activity in EC cells. Moreover, curcumin treatment significantly decreased the levels of the phosphorylated form of extracellular signal-regulated kinase (ERK) 1/2. MEK1 overexpression partially blocked the anti-metastatic effects of curcumin. Combined treatment with ERK inhibitor U0126 and curcumin resulted in a synergistic reduction in MMP-2/-9 expression; the invasive capabilities of HEC-1B cells were also inhibited. In conclusion, curcumin inhibits tumor cell migration and invasion by reducing the expression and activity of MMP-2/9 via the suppression of the ERK signaling pathway, suggesting that curcumin is a potential therapeutic agent for EC…”

 “Abstract-  The possibility that dietary vitamin D3 (VD3) exposure inhibits endometrial carcinogenesis in an animal model and modifies the enhanced risk of endometrial carcinoma associated with obesity was investigated.
Although VD3 did not affect EC risk, it inhibited obesity-induced increase in endometrial lesions. Specifically, high-fat diet increased focal glandular hyperplasia with atypia and malignant lesions from 58% in the control diet–fed Pten+/− mice to 78% in obese mice.
Our data confirm the known association between obesity and EC risk. Dietary exposure to VD3 inhibited the carcinogenic effect of obesity on the endometrium. This protective effect was linked to a reduction in the expression of osteopontin and increase in E-cadherin.”

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