Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Numerous studies correlate the importance of Vitamin D3 with numerous chronic diseases. Multiple Myeloma in particular. Or should I say that low blood levels of vitamin D3 are associated with many diseases? Multiple Myeloma in particular.
As a multiple myeloma survivor and MM cancer coach, I have learned that the issue is not how much vitamin D3 to take. Dosing won’t tell you what you need to know about your serum blood levels of vitamin D3.
Vitamin D3 is not an integrative or a complementary therapy the way that say…curcumin or exercise are. Testing your blood for your vitamin D3 levels is more of a MM diagnostic marker.
The trick is to learn about what your individual serum blood Vitamin D3 level is.
I live in Cleveland, Ohio. I am a MM survivor who has a long-term risk of non- melanoma skin cancer. I stay out of the sun. Therefore, I need to supplement with Vitamin D3. The numbers listed below are taken from LabCorp blood testing in 2009. 2011 and 2014.
My blood levels of vitamin D3 are within the normal range but just barely. And the levels below are after I began supplementing with vitamin D3 daily- 1000 ng x 2 daily. The RDA for vitamin D3 is 400-400 IU. Based on my experience, this is too little but that is for you to determine based on your own blood levels.
I take Life Extension Vitamin D3 because this brand has been tested and approved by ConsumerLab.com an independent testing service. I encourage you to have your blood checked for Vitamin D3 and, depending on your results, supplement with Vitamin D3 .
Vitamin D, 25-Hydroxy 36.9 ng/mL 32.0-100.0
Vitamin D, 25-Hydroxy 38.8 ng/mL 32.0-100.0
Vitamin D, 25-Hydroxy 31.9 ng/mL 30.0-100.0
Here, we studied 83 unselected multiple myeloma patients from December 2007 through December 2014. Lower 25(OH) D levels (<10 ng/mL) were associated with higher number of plasma cells in the bone marrow.
Supplementation of vitamin D was accompanied with a significant increase in hemoglobin (11.8 to 12.3 p = .039), leukocyte (4.9 to 5.8 p = .011), and erythrocyte (3.8 to 4.0 p = .004) levels, while thrombocytes (200.5 to 175.2 p = .036) decreased.
In conclusion, the present study found a high incidence of vitamin D deficiency and insufficiency in MM patients.
In myeloma patients, vitamin D levels and supplementation should be more widely taken into account.
“Elevated 25-hydroxyvitamin D concentrations are inversely correlated with cancer risk, according to a study published in the BMJ…
The primary outcome was the incidence of overall or specific cancer. The investigators selected 4044 random subgroup volunteers to match the 3301 cancer patients and measured the concentration of plasma 25-hydroxyvitamin D with an enzyme immunoassay.
Participants were sorted into quarters based on gender- and season-specific distributions of 25-hydroxyvitamin D, and hazard models were calculated using statistical analysis. Of the separated groups, the lowest quarter was used as the reference.
The researchers reported that increased circulating 25-hydroxyvitamin D concentrations were negatively correlated with total cancer risks for the second, third, and fourth quarter groups. Using the first quarter’s multivariable-adjusted hazard ratio (HR) as the reference, the investigators found that the second, third, and fourth quarters resulted in a reduced risk for cancer (HR, 0.81, 0.75, and 0.78, respectively)…”
“CONCLUSIONS: In this large cohort study, serum 25(OH)D concentrations were inversely associated with all-cause and cause-specific mortality. In particular, vitamin D deficiency [25(OH)D concentration <30 nmol/L] was strongly associated with mortality from all causes, cardiovascular diseases, cancer, and respiratory diseases.
Fact Sheet for Health Professionals
“Vitamin D is a fat-soluble vitamin that is naturally present in very few foods, added to others, and available as a dietary supplement. It is also produced endogenously when ultraviolet rays from sunlight strike the skin and trigger vitamin D synthesis….
Serum concentration of 25(OH)D is the best indicator of vitamin D status…
Based on its review of data of vitamin D needs, a committee of the Institute of Medicine concluded that persons are at risk of vitamin D deficiency at serum 25(OH)D concentrations <30 nmol/L (<12 ng/mL). Some are potentially at risk for inadequacy at levels ranging from 30–50 nmol/L (12–20 ng/mL). Practically all people are sufficient at levels ≥50 nmol/L (≥20 ng/mL); the committee stated that 50 nmol/L is the serum 25(OH)D level that covers the needs of 97.5% of the population. Serum concentrations >125 nmol/L (>50 ng/mL) are associated with potential adverse effects  (Table 1).”
“Relative to participants with a concentration of 50 nmol/L, participants with less than 25 nmol/L had approximately 20% higher odds of RCC. Correspondingly, participants with concentrations greater than 100 nmol/L had 20% lower odds of RCC relative to those with a concentration of 50 nmol/L, but very few participants had concentrations as high as 100 nmol/L.”
“Patients who have genetically low vitamin D appear to be at an increased risk of premature death, according to a mendelian randomization study reported in BMJ…