Will histotripsy reduce the side effects that result from cancer therapy? About 30% of PeopleBeatingCancer is dedicated to the adverse events aka side effects that can result from chemotherapy and radiation. All I have to do is research and write about my own short, long-term and late stage side effect.
Though histotripsy is comparatively new as cancer therapies go, I am blogging about it because I think it has a great deal of potential for cancer patients in the future.
Histotripsy is a non-invasive medical procedure that uses high-intensity ultrasound waves to break down tissue. It is a form of therapeutic ultrasound that can be used for a variety of medical applications, including tissue ablation.
In histotripsy ablation, focused ultrasound waves are directed at a target tissue. The waves create tiny bubbles within the tissue, and when these bubbles collapse or implode, they generate mechanical forces that break down the tissue into a fine particulate matter. This process is called cavitation.
As with any medical procedure, the decision to use histotripsy should be made after careful consideration of the individual patient’s condition, the expertise of the medical team, and a thorough discussion of the potential risks and benefits.
Keep in mind that while histotripsy is a promising medical technique, its specific applications and availability may vary based on factors like location, healthcare facility, and the latest advancements in the field of medical technology. Always consult a qualified healthcare professional for the most up-to-date and accurate information regarding medical procedures and treatments.
“Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technology guided by real-time imaging. Using focused ultrasound delivered from outside the body, histotripsy mechanically destroys tissue through cavitation, rendering the target into acellular debris.
The material in the histotripsy ablation zone is absorbed by the body within 1–2 months, leaving a minimal remnant scar. Histotripsy has also been shown to stimulate an immune response and induce abscopal effects in animal models, which may have positive implications for future cancer treatment.
Histotripsy has been investigated for a wide range of applications in preclinical studies, including the treatment of cancer, neurological diseases, and cardiovascular diseases.
Three human clinical trials have been undertaken using histotripsy for the treatment of:
This review provides a comprehensive overview of histotripsy covering the origin, mechanism, bioeffects, parameters, instruments, and the latest results on preclinical and human studies…
This section summarizes the preclinical studies for tumors outside the brain, including
In addition, histotripsy has been shown to stimulate an immune response with a subsequent abscopal effect in animal tumor models, which is described in g) Immune Response. For the large animal (porcine, canine, and rabbit) models, frequencies between 700 kHz and 1 MHz were used. For small animal (rodent and murine) models, a 1 MHz small animal system was used. Other parameters are listed in Table 1…