Multiple Myeloma Requires “Body-wide Immune Response”

There is a long and growing list of FDA approved chemotherapy regimens that are cytotoxic to Multiple Myeloma (MM). When newly diagnosed MMers undergo a typical induction therapy such as RVD (revlimid, velcade and dexamethasone) they are almost guaranteed that their MM will respond. The challenge that all MMers face is that MM always comes back. MMers always relapse. 

The article linked below talks about the need for a body-wide immune response to fight off cancer. It makes sense to me that since MM is a systemic or body-wide cancer, MM requires a body-wide immune response.

I believe that the evidence-based, non-toxic, anti-MM regimen that I follow daily provides a body-wide immune response that has kept me in complete remission from my MM since 1999. I rely on anti-MM nutrition, supplementation, bone health, lifestyle and even mind-body therapies to keep me in CR from my MM.

Image result for photo of cancer relapse

To learn more about MM cancer coaching scroll down the page, post a question or comment and I will reply to you ASAP.

David Emerson

  • MM Survivor
  • MM Cancer Coach

Bodywide immune response important for fighting cancer, researchers say

“Fighting off cancer requires the concerted efforts of immune molecules throughout the body, rather than just in the tumor itself…

This finding suggests that, although the initial immune response occurred primarily in the tumor, immune responses in other parts of the body are likely responsible for sustaining the immune attack

“In the past, researchers focused on understanding in very minute detail what is happening at the molecular level in immune cells inside the tumor,” said Engleman. “But we took an approach that allowed us to zoom out and look at the immune system as a whole. This enabled us to unveil how immune cells work together throughout the body to reject a tumor, and the approach promises to be widely useful in many clinical situations.”

Posted in Newly Diagnosed, non-conventional therapies, nutrition Tagged with:

Chemo-Brain Affects Most Myeloma Patients

Not only does chemo-brain exist but according to the article below, chemo-brain affects most MMers.

That’s tens of thousands of myeloma survivors currently living with short, long-term and late stage side effects in addition to living with the fear of relapse.

There are climate-change deniers and there are chemo-brain deniers. There have been chemo-brain deniers ever since I first suspected that I suffered from chemotherapy-induced cognitive dysfunction aka chemo-brain. Or I should say that conventional oncology questions toxic chemotherapy as the cause of chemo-brain.

It is clear that chemotherapy causes chemo-brain because, again according to the article below, the more toxicity myeloma patient undergo the more chemo-brain occurs.

The good news is that I believe we MMers can heal our chemo-brain. In fact, I follow chemo-brain healing regimen daily, weekly and monthly. Just as importantly I think if you act early enough in your therapy you can reduce the risk of this awful side effect. 

Related image

I have lived with multiple myeloma since my original diagnosis in 1994. I have lived in complete remission since April of 1999. If you would like to learn more about healing your chemo-brain and/or managing your multiple myeloma, scroll down the page, post a question or a comment and I will reply ASAP.

Thank

David Emerson

  • MM Survivor
  • MM Cancer Coach

“Chemo Brain” May Affect Half Of Myeloma Patients After Initial Therapy, And Is Worsened By Stem Cell Transplantation

“Results from a recent study indicate that many myeloma patients are like­ly to suffer im­paired cog­ni­tive func­tion after their initial multiple mye­lo­ma therapy, and stem cell trans­planta­tion often causes further im­pairment,

Nearly half of the patients in the study had cog­ni­tive im­pair­ment, often referred to as ‘chemo brain,’ after receiving initial anti-myeloma therapy.  Half of the patients experienced further im­pair­ment of cog­ni­tive function at one month and again at three months following autologous (own) stem cell trans­planta­tion

In addition, they note that older patients, minorities, those with more advanced disease, more induction cycles, or impaired cog­ni­tive function following induction therapy were at greater risk for further cog­ni­tive im­pair­ment following stem cell trans­planta­tion.

Based on their results, the investigators suggest that patients who undergo autologous stem cell trans­planta­tion, particularly those who expect to resume work that involves high cog­ni­tive demand, be made aware of the risk of cog­ni­tive im­pair­ment following trans­planta­tion and offered counseling or support….”

 

Posted in non-conventional therapies, nutrition, side effects ID and prevention Tagged with:

MGUS- Lose Weight-Reduce Risk of Progression to MM

I don’t believe in diets. But I do believe that MGUS patients can change their lifestyle, lose weight and reduce their risk of progressing to Multiple Myeloma. Further, the same diet and lifestyle therapies have been shown to both starve multiple myeloma while also being cytotoxic to MM. Talk about a win-win.

Excess weigh causes inflammation. Inflammation is linked to cancer. The study below cites that overweight MGUS patients have almost twice the risk of MGUS becoming full blown multiple myeloma.

 

                                           Obesity is associated with increased risk of a number of cancers.
                           Obesity is associated with increased risk of a number of cancers.
I am both a long-term MM survivor and MM cancer coach. I didn’t try to but I have lost about 20 pounds by living an evidence-based, non-toxic, anti-MM lifestyle that has keep me in complete remission from my MM since 4/99.
If you are an MGUS patient and would like to learn more about anti-MM foods that can help you lose weight, and learn about anti-inflammatory supplements that will also help reduce your risk of a full blown MM diagnosis, please scroll down the page, post a question or comment. I will reply to you ASAP.
Thanks and hang in there,
David Emerson
  • MM Survivor
  • MM Cancer Coach

Obesity Increases Risk for Transformation of MGUS to Multiple Myeloma

“Obesity and black race are associated with an increased risk for transformation of monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma…

During a median follow-up of 68 months, 329 (4.2%) patients with MGUS progressed to multiple myeloma, including 72 (3.5%) normal-weight patients, 144 (4.6%) overweight patients, and 113 (4.3%) obese patients.

After adjusting for multiple variables, researchers found that obese patients had a nearly 2 times higher risk for progressing to multiple myeloma than normal-weight patients…”

Posted in Newly Diagnosed, non-conventional therapies, nutrition Tagged with:

Multiple Myeloma-More Chemo Is Not Better-

Two concepts have become standard practice in the treatment of multiple myeloma- low-dose maintenance therapy and metronomic therapy.

If you click the links and read the info,  you will see that the terms overlap each other. You will see that conventional MM oncology has determined that low, regular doses of anti-MM therapy give the longest, deepest remissions for MMers.

Further, more toxic chemotherapy means a greater risk of short, long-term, late stage side effects and secondary cancers.

The study linked and excerpted below establishes the same thing. Basically that pumping MMers full of cytotoxic chemotherapy does NOT give the MMer longer remissions (PFS) or longer life (OS).

What if I told you that I have remained in complete remission from my MM since 4/99 with the help of non-toxic, low-dose maintenance and metronomic therapies?

I am a long-term MMer and MM Cancer Coach. The MM CC program incorporates the evidence-based info and therapies below:

  1. Listing of the most successful MM specialists and hospitals
  2. Dozens of foods that starve MM (anti-MM) foods
  3. More than 15 integrative therapies that synergize with five common MM chemotherapy regimens,
  4. Over a dozen evidence-based mind-body therapies,
  5. Detoxification therapies,
  6. Both conventional and non-conventional bone health therapies
  7. Review and links to more than 20 online MM support groups
  8. Studies reviewing Cannabis/CBD as integrative MM therapy, pain therapy and stand-alone MM therapy-

Image result for image of less is more

Scroll down the page, post a question or comment and I will reply to you ASAP.

 

Thanks,

David Emerson

More Treatment Does Not Necessarily Mean More Benefit in Multiple Myeloma 

More treatment does not necessarily offer more benefit for patients—at least when it comes to multiple myeloma

Although lenalidomide maintenance (low-dose Revlimid) after AHCT has improved PFS and OS, the role of additional interventions after AHCT, such as tandem AHCT or triple therapy consolidation, remains to be determined…

In the era of thalidomide analogs and proteasome inhibitors used in the initial therapy for myeloma and the use of prolonged maintenance therapy with lenalidomide (low-dose maintenance Rev.), posttransplant consolidation with cycles of RVD or a second transplant do not produce incremental PFS benefit,””

Posted in Newly Diagnosed

Multiple Myeloma- Diagnosis and Staging

The diagnosis of cancer can be devastating. A diagnosis of an incurable cancer can be beyond devastating. If you have been told that you have multiple myeloma (MM), an incurable blood cancer, your challenge is to keep your wits about you so that you can determine the stage of your MM.
Illustration of multiple myeloma plasma cells

Why? Your age, physical condition, stage, symptoms, genetic abnormalities, etc. can mean that your prognosis is anywhere from 3 years to 23 years.  Your stage of MM can be determined by tests such as a Serum Protein Electrophoresis (SPEP), bone marrow biopsy (BMB), or imaging studies such as x-rays, CT scans or MRI scans.

I’m telling all this not to confuse you but to explain the importance of staging to YOU, the newly diagnosed MMer.

I am both a long-term MM survivor and MM cancer coach. I need to understand your stage at diagnosis, symptoms and goals in order to help you figure out your therapies, both conventional (FDA approved ) or non-conventional. Understanding your MM will help figure out how MM cancer coaching can help you manage your cancer.

  1. Listing of the most successful MM specialists and hospitals
  2. Dozens of foods that starve MM (anti-MM) foods
  3. More than 15 integrative therapies that synergize with five common MM chemotherapy regimens,
  4. Over a dozen evidence-based mind-body therapies,
  5. Detoxification therapies,
  6. Both conventional and non-conventional bone health therapies
  7. Review and links to more than 20 online MM support groups
  8. Studies reviewing Cannabis/CBD as integrative MM therapy, pain therapy and stand-alone MM therapy-

If you would like to talk to a MM cancer coach about your situation, scroll down the page, post a question and I will reply to you ASAP.

Thanks and hang in there,

David Emerson

  • MM Survivor
  • MM Cancer Coach

 

Diagnosing multiple myeloma from test results

A diagnosis of multiple myeloma requires either:

  • High blood calcium level
  • Poor kidney function
  • Low red blood cell counts (anemia)
  • Holes in bones from tumor growth found on imaging studies
  • An abnormal area in the bones or bone marrow on an MRI scan
  • Increase in one type of light chains in the blood so that one type is 100 times more common than the other

OR

2. 60% or more plasma cells in the bone marrow

Posted in Newly Diagnosed, nutrition Tagged with:

Multiple Myeloma and Stress

Can stress cause cancer?  I believe that stress contributed to my multiple myeloma diagnosis but there are few if any studies that draw a clear line from stress to multiple myeloma. More than likely my diagnosis of multiple myeloma was caused by working in a commercial printing plant from ’88-’94.

Related image

The NYT article linked and excerpted below cites a study that shows how stress can increase inflammation, a known cause of cancer. Many of the evidence-based therapies in MM cancer coaching such as supplementation (curcumin), nutrition, lifestyle, detoxification and even mind-body therapies have been shown to reduce inflammation. Myeloma requires a combination conventional and non-conventional therapies.

  1. Listing of the most successful MM specialists and hospitals
  2. Dozens of foods that starve MM (anti-MM) foods
  3. More than 15 integrative therapies that synergize with five common MM chemotherapy regimens,
  4. Over a dozen evidence-based mind-body therapies,
  5. Detoxification therapies,
  6. Both conventional and non-conventional bone health therapies
  7. Review and links to more than 20 online MM support groups
  8. Studies reviewing Cannabis/CBD as integrative MM therapy, pain therapy and stand-alone MM therapy

Can reducing stress and inflammation reduce your risk of myeloma relapse?

I am both a long-term MM survivor and MM cancer coach. I have remained in complete remission from my MM since early 1999.

To learn more about evidence-based, non-toxic, multiple myeloma therapies scroll down the page and write a post. I will reply to you ASAP.

Thanks

David Emerson

  • MM Survivor
  • MM Cancer Coach

Stress May Counteract Effects of a Healthful Diet

“Stress may counteract the beneficial effects of a healthful diet, a study in Molecular Psychiatry suggests...

Among women who had low levels of stress, markers of inflammation tended to be higher after eating the meal containing high levels of saturated fat than after the low saturated fat meal.

But for women who had high levels of stress, those differences disappeared — they had high levels of inflammation even after the meal that was low in saturated fats.

The surprise here is that stress made the healthier-fat meal look like the saturated-fat meal…

 

Posted in Newly Diagnosed, non-conventional therapies, nutrition Tagged with:

MGUS-“comparatively lower life expectancy”

MGUS stands for monoclonal gammopathy of undermined significance. MGUS is not cancer. It is a pre-Multiple Myeloma (MM) asymptomatic blood disorder. The challenge with a diagnosis of MGUS is that it can lead to a diagnosis of multiple myeloma, an incurable blood cancer. And according to the article below,  “MGUS cohorts have a comparatively lower life expectancy…”

As the article linked and excerpted below states, “““The risk of progression is approximately 1% per year,…”The important point to keep in mind is that this 1% per year persists indefinitely, I believe.””

The question is, can the MGUS patients reduce or eliminate his/her risk of MGUS progressing to MM? Yes, according to the short video titled “Turmeric Curcumin, MGUS and MM” linked below. According to the study talked about in the video, curcumin and diet can slow the progression of MGUS to MM.

I am both a long-term MM survivor and MM cancer coach. If you are interested in learning more about MM Cancer Coaching guides encompassing the therapies below, scroll down the page, post a question or a comment and I will reply to you ASAP.

  1. 16 non-toxic, cytotoxic/apoptotic supplements,
  2. dozens of  anti-MM foods
  3. integrative therapies that synergize with five common MM chemotherapy regimens,
  4. over a dozen evidence-based mind-body therapies,
  5. detoxification therapies,
  6. thorough discussion of bone health therapies including a dozen non-conventional bone health therapies
  7. review and links to more than 20 online MM support groups
  8. links to the most successful MM specialists and hospitals

And more…

David Emerson

  • MM Survivor
  • MM Cancer Coach

Turmeric Curcumin, MGUS, and Multiple Myeloma

MGUS may progress to multiple myeloma, AL amyloidosis, Waldenstrom’s macroglobulinemia, or lymphoma. But not all cases progress to malignancy.
MGUS may progress to multiple myeloma, AL amyloidosis, Waldenstrom’s macroglobulinemia, or lymphoma. But not all cases progress to malignancy.

MGUS: Determining Significance in Multiple Myeloma

“Much, however, remains a mystery, including the curious fact…that MGUS cohorts have a comparatively lower life expectancy, “which is not entirely explained by the risk of malignant transformation.”1

“The median interval from recognition of the monoclonal protein to diagnosis of multiple myeloma was 64 months,” he (Dr. Robert Kyle) wrote in his landmark study, “of macroglobulinemia 103 months and of amyloidosis 92 months.”

“The risk of progression is approximately 1% per year,” Dr Kyle explained by phone. “The important point to keep in mind is that this 1% per year persists indefinitely, I believe.”

The risk factors for progression include the size of the serum M protein, the protein type, the number of plasma cells in the bone marrow, and the serum free light chain ratio…

 

Posted in Newly Diagnosed, non-conventional therapies, nutrition Tagged with:

Multiple Myeloma- Intravenous Vitamin C Therapy

intravenous vitamin C (ascorbic acid and L-ascorbic acid) therapy is the ideal complimentary, non-toxic, non-conventional therapy for myeloma patients and survivors. At least it is from my perspective as a long-term MMer and MM cancer coach.

I believe that conventional chemotherapy regimes such as Velcade, Revlimid, Darzalex, etc. can kill MM.  Achieving remission after induction therapy, especially if you have minimal side effects is a great feeling. The two challenges for MMers is 1) collateral damage aka side effects and 2) MDR aka multi-drug resistance. Side effects can increase with the more chemo you have and the day will come when you relapse and conventional chemotherapy regimens no longer work.

The articles linked and excerpted below spell out how intravenous vitamin-C therapy kills or will weaken myeloma exposing your cancer to being killed by cytotoxic therapies or the evidence-based nutrition, supplementation and other therapies that show results in myeloma therapy.

A discussion of intravenous vitamin C as a non-conventional myeloma therapy is listed in the non-conventional MM cancer coaching guide.

The multiple myeloma cancer coaching guides (MM CC guides) encompass evidence-based research and therapies as:

  1. 16 non-toxic, cytotoxic/apoptotic supplements,
  2. dozens of anti-angiogenic (anti-MM) foods
  3. more than 15 integrative therapies that synergize with five common MM chemotherapy regimens,
  4. over a dozen mind-body therapies,
  5. detoxification therapies,
  6. thorough discussion of bone health therapies including a dozen non-conventional bone health therapies
  7. review and links to more than 20 online MM support groups
  8. links to the most successful MM specialists and hospitals

If you would like to learn more about managing your MM with both conventional and non-conventional therapies, scroll down the page and post a comment. I will reply to you ASAP.

Thanks

David Emerson

 Citrus fruits were one of the first sources of vitamin C available to ships’ surgeons.

Why high-dose vitamin C kills cancer cells

“Vitamin C breaks down to generate hydrogen peroxide, which can damage tissue and DNA. The new study shows that tumor cells with low levels of catalase enzyme activity are much less capable of removing hydrogen peroxide than normal cells, and are more susceptible to damage and death when they are exposed to high doses of vitamin C…

Most vitamin C therapies involve taking the substance orally. However, the UI scientists have shown that giving vitamin C intravenously — and bypassing normal gut metabolism and excretion pathways — creates blood levels that are 100 — 500 times higher than levels seen with oral ingestion. It is this super-high concentration in the blood that is crucial to vitamin C’s ability to attack cancer cells….”

Vitamin C in complementary oncology–update 2009.

“The antioxidant perhaps most widely used in complementary oncology is vitamin C, particularly by intravenous injection. In light of the recent clinical pharmacokinetic findings, the in vitro evidence of anti-tumour mechanisms and some well-documented cases of advanced cancers the role of high-dose intravenous vitamin C therapy in cancer treatment should be reassessed…”

 

Posted in Uncategorized

Multiple Myeloma- Partnering with your Oncologist

The longest living MMer that I know of is Jim Bond. Jim was first diagnosed with MM in 1991 and is alive and well  today (1/5/17). Though I have never seen a study that tries to quantify “partnering with your oncologist” I have to believe that it makes a real difference in an MMers long-term survival. If any MMer understands how to partner with an oncologist it is long-term MM survivor Jim Bond.
The comments below are excerpted from Jim’s experiences regarding working with one’s oncologist in general.
“To us, partnering with doctors means the patient is an equal partner. We do not try to be the boss, but we try to get our view fully considered before a decision is made. E.G., several years ago when my MM level began to rise, my doctor wanted to add a second drug to the one I was taking as maintenance. We wanted to raise the dose of the maintenance drug without adding the second drug. Our thinking would save the second drug for when we may need it later.
After a couple phone calls, we convinced our doctor to give our way a try even though 
It was not his preference. A key was our agreeing that if our approach did not quickly show results, we would agree to adding the second drug, Our nurse was vital to advocating our position. Our way worked, and my doctor called and said, ” good call” 
to us. 
There are more examples, but I wanted to clarify partnering from your good interpretation that we call researching and staying informed of what is on the horizon. This is also important, along with: being compliant with the drug schedule and recognizing that each mm case is different. These 3 make 7 total key items which make the word, respect.
  • Research what’s on the horizon
  • Exercise in some way each day
  • Second opinions when appropriate
  • Partnering with our medical team
  • Each case is different
  • Compliance with drug and vitamin schedule 
David, I have not seen this technique anywhere. I am happy to share my thinking with others. If you do, please attribute it to us.
James D. Bond
July 27 – 30, 2017″
Posted in All Tagged with:

Multiple Myeloma- Experience-based Clinical Trial Results

I’ve written blogs on PBC over the years questioning aspects of clinical trials. A great friend of mine, Jim Bond,  has lived with multiple myeloma since his diagnosis in 1991, came across one of my clinical trial blog posts today and wanted to add some experienced-based clinical trial results.

Jim has benefited greatly from his clinical trial experience. I don’t think Jim is exaggerating when he says that clinical trials have saved his life.

Hi David,

Thanks for all you do to help those of us with cancer. As you know, I was diagnosed with stage 3 multiple myeloma and told by major cancer cener I would live 3 years at most. That was 25 years ago.  I have been physically active throughout these 25 years. Much of our story is available by searching my name, James Bond, with multiple myeloma.

I believe clinical trials, second opinions, daily exercise, and partnering with our medical team are key reasons for my robust survival. To date, I have entered 6 clinical trials, which helped at least 2 new myeloma drugs get FDA approval. I was always treated very well in each clinical trial. I would have died in 2002 without one clinical in particular. Contact me at Jim.bond48@gmail.com for my beliefs that more of us should enter clinical trials, if they make sense to our situation.

I am passionate about raising funds for ACS Hope Lodges by riding 328 miles over 4 days 10 straight years in the POHR because I know a real obstacle to leaving town for a clinical trial can be lodging money which may not be available. Staying free in one of 32 ACS Hope Lodges or in other free hotel rooms that resulted from the POHR helps overcome this obstacle.
 
Other supposed obstacles I hear from patients I do not believe are valid reason to avoid clinical trials. Here are common ones:

–I will be treated like lab rat. Not my experience at all

–I will offend my local doctor. You have the wrong doc if he/she places their practice above your health

–I may be given a placebo. In virtually all cancer clinical trials, patients get the standard of care ( if one exists) or the new drug or combo being tested. As soon as one trial arm shows significantly better results, patients are advised to switch to the more beneficial arm. I have personally seen this happen.

–the trial doc will care more about the experimental drug than my health. I saw just the opposite, the docs and nurses cared as much about me as when I was not in a trial.

According to the ACS, Virtually all major advances in cancer treatments have come from clinical trials. No one has funded more scientists (47) than the ACS. The ACS saved my life twice (so far).

 
Regards,

Jim

July 27 – 30, 2017
Posted in Newly Diagnosed Tagged with:

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