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MGUS Risk Factors

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According to the research linked and excerpted below, obesity, smoking and sleep are all factors that increase the risk of  being diagnosed with monoclonal gammopathy of undetermined significance (MGUS).

If there are modifiable risk factors that can increase your risk of MGUS then it follows that there are also modifiable factors that can reduce your risk of MGUS.

What factors can increase your risk of monoclonal gammopathy of undetermined significance?

Monoclonal Gammopathy of Undetermined Significance (MGUS) is a condition characterized by the presence of an abnormal protein (monoclonal protein) in the blood. The exact cause of MGUS is not well understood, and in many cases, it occurs without a clear explanation. However, there are some factors that may be associated with an increased risk of developing MGUS:

  1. Age: MGUS is more common in older individuals, and the risk increases with age.
  2. Gender: Men are generally at a higher risk of developing MGUS compared to women.
  3. Race: There is evidence to suggest that African Americans may have a higher risk of MGUS compared to other racial groups.
  4. Family History: There may be a genetic component to MGUS, as individuals with a family history of the condition may be at a higher risk.
  5. Other Plasma Cell Disorders: Individuals with a history of other plasma cell disorders, such as multiple myeloma, may be at an increased risk of developing MGUS.
  6. Occupational Exposures: Some studies have explored the potential link between certain occupational exposures and an increased risk of MGUS, but the evidence is not conclusive.

I am a long-term survivor of multiple myeloma. I live an anti-MM lifestyle. Meaning, I am a MM survivor who achieved CR in early 1999 and I have been living my life in hopes of reducing my risk of another MM diagnosis. I have worked to reduce any/all modifiable risk factors in my life that may increase my risk of multiple myeloma.

I get a full nights sleep each and every night, I exercise daily ( I weight less not than I did in college) and I have never smoked. To this lifestyle I add:

Have you been diagnosed with a form of pre-myeloma- MGUS or SMM? Would you like to pursue evidence-based therapies shown to reduce your risk of an MGUS diagnosis?

Let me know- David.PeopleBeatingCancer@gmail.com

Hang in there,

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Mass spectrometry-detected MGUS is associated with obesity and other novel modifiable risk factors in a high-risk population

  • Among individuals at elevated risk of multiple myeloma, obesity is positively associated with mass spectrometry-detected MGUS.
  • High physical activity is inversely associated with MGUS, whereas heavy smoking and short sleep are positively associated with MGUS.
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition of multiple myeloma with few known risk factors.
The emergence of mass spectrometry (MS) for the detection of MGUS has provided new opportunities to evaluate its risk factors.
2628 individuals at elevated risk for multiple myeloma were enrolled in a screening study and completed an exposure survey (PROMISE; ClinicalTrials.gov, #NCT03689595). Participant samples were screened by MS, and monoclonal proteins (M-proteins) with concentrations >0.2 g/L were categorized as MS-MGUS.
Multivariable logistic models evaluated associations between exposures and MS outcomes. Compared to normal weight (BMI: 18.5 to <25 kg/m2), obesity (BMI: >30 kg/m2) was associated with MS-MGUS, adjusting for age, sex, Black race, education, and income (odds ratio [OR] = 1.73, 95% confidence interval [CI] = 1.21 to 2.47, P = .003).
Modifiable Risk Factors in MGUS:
  • High physical activity had a decreased likelihood of MS-MGUS,
  • whereas heavy smoking and
  • short sleep had increased likelihood of MS-MGUS  and sleep 
In the analysis of all MS-detected monoclonal gammopathies, which are inclusive of M-proteins with concentrations <0.2 g/L, elevated BMI and smoking were associated with all MS-positive cases.
Findings suggest MS-detected monoclonal gammopathies are associated with a broader range of modifiable risk factors than what has been previously identified.”

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