“Our study suggests that EPA and DHA induce selective cytotoxic effects in MM and increase sensitivity to bortezomib… but curcumin inhibited MM cell growth”
Hi David- My 60 year old sister was diagnosed with Multiple Myeloma about 3 years ago. She has had constant MM chemotherapy throughout and an autologous stem cell transplant (ASCT) about 1 year ago. She has been taking many supplements/vitamins all along. Doctors say she has refractory MM and in most cases the life span (with treatments) is only 5 years.
Could supplements/vitamins be interacting with the chemo treatments preventing her from going into remission? Laura
I am sorry to learn of your sister’s refractory MM. I interpret your oncologists using this term to mean that your sister’s MM is resistant to chemotherapy. While it is not often discussed in the MM literature, 20-25% of newly diagnosed multiple myeloma patients are resistant to chemotherapy aka refractory. Please see the study below.
For the record, my MM was refractory as well. Meaning, I never achieved satisfactory remission after my induction chemotherapy nor did I achieve satisfactory after my autologous stem cell transplant. In fact, my MM stage increased after my induction therapy.
As for your question “Could supplements/vitamins be interacting with the chemo treatments preventing her from going into remission?” It is impossible for me to answer this question fully without knowing which nutritional supplements your sister is taking.
- However, I can say that certain supplements have been shown in studies to enhance the efficacy of specific MM chemotherapy regimens. For example, curcumin has been shown to enhance the efficacy of revlimid (lenalidomide). See the study linked below.
- In addition, omega-3 fatty acids have been shown to kill MM as well as enhance the efficacy of velcade (bortezomib). Please see the study below.
- On the other hand, green tea (EGCG) has been shown to inhibit the efficacy of velcade (bortezomib).
Conventional FDA approved oncology doesn’t study, doesn’t research most nutrition supplements. That’s just not what they or the FDA does. Therefore, the challenge for all MM patients is to figure out what therapies give us the best chances for survival.
If you would like, send me a list of those supplements that your sister takes and I will be happy to research possible interactions with MM and MM chemotherapy regimens.
Let me know, hang in there,
- MM Survivor
- MM Coach
- Director PeopleBeatingCancer
“The majority of patients with multiple myeloma (MM) will have an initial response to treatment with modern combination regimens. However, conventional therapy is not curative and most of these patients will ultimately progress. In addition, some patients will not respond to initial treatment (ie, refractory disease)…”
“…The results presented here showed that MM cells co‐cultured with BMSCs grew faster at 24h, but curcumin inhibited MM cell growth, with or without the presence of co‐cultured BMSCs at 72h…”
“Our study suggests that EPA and DHA induce selective cytotoxic effects in MM and increase sensitivity to bortezomib and calls for further exploration into a potential application of these n-3 polyunsaturated fatty acids in the therapy of MM.”
“The anticancer potency of green tea and its individual components is being intensely investigated, and some cancer patients already self-medicate with this “miracle herb” in hopes of augmenting the anticancer outcome of their chemotherapy…
Unexpectedly, we discovered that various green tea constituents, in particular (-)-epigallocatechin gallate (EGCG) and other polyphenols with 1,2-benzenediol moieties, effectively prevented tumor cell death induced by BZM in vitro and in vivo…
Taken together, our results indicate that green tea polyphenols may have the potential to negate the therapeutic efficacy of BZM and suggest that consumption of green tea products may be contraindicated during cancer therapy with BZM.”