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Multiple Myeloma Treatment- CBD w/ Velcade, Darzalex, Kyprolis?
“These results showed that CBD by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death…”
Hi David- I am a 60 year old Multiple Myeloma patient. After my diagnosis and induction multiple myeloma treatment I experienced three years of remission. I have now relapse happened. So I am back on Dexamethasone, Darzalex, Revlimid & now my calcium hiked to 11 points. This result is a bit in the above the “normal” range, so next week onwards, Kyprlis is added.
I am doing ok, don’t have severe side effects other than moderate numbness on the feet. My sleep is broken. General weakness is there and moderate pain on the back and both side of the rib cage.
I live with wife (NP-hospice) and son in Dallas, Texas.
Today I took two drops hemp CBD oil water-soluble (500mg, with no THC) and found a bit relaxed in my pain.
So I am wondering, what dosage I shall take regularly, and is it going to affect my treatment? I have no known heart, kidney or liver issues. I go for walks, but my activities are limited due to tiredness and back pain.
Please advise what else I can do to improve my life and live with this better. I am an artist by profession, but I cannot paint for a long time now. This makes me depressed at times. I do not drink or smoke and I don’t eat meat, but fish and veg a lot.
I am pretty impressed by the excellent service you are doing, and the hope that permeates from your words.
Thanks in advance, Sebastian
Dear Sebastian,
Thank you for your kind words. I am sorry to learn of your MM relapse as well as the side effects you are struggling with. I will link blog posts and studies below that I think may help your situation. I hope that active MM treatment, both conventional and non-conventional therapies, will help you feel normal and get back to your painting!
Regarding your question “So I am wondering, what dosage I shall take regularly, and is it going to affect my treatment?” Several issues:
- Cannabidiol aka CBD oil has been shown to integrate or enhance the efficacy of kyprolis (carfilzomib) and bortezomib (velcade). See link below.
- Cannabidiol aka CBD oil has also been shown to treat pain and heal bones.
Both of these reasons may be why you “feel a bit relaxed in your pain.” Having said that, it is almost impossible to answer your question about dosage more specifically. The challenge is
- all states have different dispensaries, offer different strains of CBD oil.
- each strain can have different amounts of, different percentages of cannabinoids. It is cannabinoids that research has shown enhance Velcade, are cytotoxic to MM, heal bones, and treat pain.
The most information I can offer regarding dosing of CBD is what I have been told by clients who take CBD themselves. People simply say that they put a couple of drops of CBD oil under their tongue the way you have, and then add a drop or two each dosing, if and when they feel comfortable doing so. There is also the cost issue to deal with. Some people need to use less, spend less.
Regarding CBD oil affecting darzalex or kyprolis, all I can offer is the available research on the issue. Studies show that CBD integrates with kyprolis (carfilzomib) and bortezomib (velcade) but there I can find no research about CBD and darzalex (daratumumab) either helping or hurting.
Let me know if you have any questions. Hang in there.
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Recommended Reading:
- Multiple Myeloma Side Effects- Acupuncture For Pain
- C-B-D In Synergy w/ Myeloma Chemotherapy
- Elderly Multiple Myeloma Diagnosis? Fasten Your Seat Belts
Using CBD Oil for Pain Management: Does It Work?
“Cannabidiol (CBD) is a type of cannabinoid, a chemical found naturally in cannabis (marijuanaand hemp) plants. CBD doesn’t cause the “high” feeling often associated with cannabis. That feeling is caused by tetrahydrocannabinol (THC), a different type of cannabinoid.
Some people with chronic pain use topical CBD products, in particular CBD oil, to manage their symptoms. CBD oil may reduce:
- pain
- inflammation
- overall discomfort related to a variety of health conditions..”
“Multiple myeloma (MM) is a plasma cell (PC) malignancy characterised by the accumulation of a monoclonal PC population in the bone marrow (BM). Cannabidiol (CBD) is a non-psychoactive cannabinoid with antitumoural activities, and the transient receptor potential vanilloid type-2 (TRPV2) channel has been reported as a potential CBD receptor.
TRPV2 activation by CBD decreases proliferation and increases susceptibility to drug-induced cell death in human cancer cells…
Because bortezomib (BORT) is commonly used in MM treatment, we investigated the effects of CBD and BORT in CD138+TRPV2- MM cells and in MM cell lines transfected with TRPV2 (CD138+TRPV2+).
These results showed that CBD by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death by regulating the ERK, AKT and NF-κB pathways with major effects in TRPV2+ cells.
These data provide a rationale for using CBD to increase the activity of proteasome inhibitors in MM…”
Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration
“Several studies showed a potential anti-tumor role for cannabinoids, by modulating cell signaling pathways involved in cancer cell proliferation, chemo-resistance and migration.
Cannabidiol (CBD) was previously noted in multiple myeloma (MM), both alone and in synergy with the proteasome inhibitor bortezomib, to induce cell death.
In other type of human cancers, the combination of CBD with Δ9-tetrahydrocannabinol (THC) was found to act synergistically with other chemotherapeutic drugs suggesting their use in combination therapy.
In the current study, we evaluated the effects of THC alone and in combination with CBD in MM cell lines. We found that CBD and THC, mainly in combination, were able to reduce cell viability by inducing autophagic-dependent necrosis.
Furthermore, since the immuno-proteasome is considered a new target in MM and also since carfilzomib (CFZ) is a new promising immuno-proteasome inhibitor that creates irreversible adducts with the β5i subunit of immuno-proteasome, we evaluated the effect of CBD and THC in regulating the expression of the β5i subunit and their effect in combination with CFZ.
Herein, we also found that the CBD and THC combination is able to reduce expression of the β5i subunit as well as to act in synergy with CFZ to increase MM cell death and inhibits cell migration.
In summary, these results proved that this combination exerts strong anti-myeloma activities…”