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I am an authority on chronic pain therapies. I say this because I live with many different long-term and late stage side effects from aggressive cancer therapies that have resulted in different types of pain and I have tried to manage my pain with seven of the evidence-based non-conventional therapies for pain listed below.
When I come across a study like the one linked and excerpted below about a chronic pain therapy I write about it in hopes that others can learn from it.
Chronic pain is long standing pain that persists beyond the usual recovery period or occurs along with a chronic health condition, such as arthritis. Chronic pain may be “on” and “off” or continuous. It may affect people to the point that they can’t work, eat properly, take part in physical activity, or enjoy life.
Non-conventional therapies for chronic pain often involve approaches that go beyond traditional medical treatments. While it’s important to consult with healthcare professionals before trying any new therapies, here are some non-conventional approaches that people with chronic pain may explore:
It’s important to note that individual responses to these therapies can vary, and what works for one person may not work for another. It’s advisable to consult with healthcare professionals and specialists who can provide personalized guidance based on the specific nature of the chronic pain condition.
Are you a cancer survivor living with chronic pain? I’m only one person so my experience is only anecdotal of course. If you’d like to learn more about chronic pain therapies with non-opioid therapies let me know- David.PeopleBeatingCancer@gmail.com
Hang in there,
“Among the most difficult types of pain to alleviate is neuropathic pain, pain that is usually caused by damage to nerves in various body tissues, including skin, muscle and joints. It can cause patients to suffer feelings like electric shocks, tingling, burning or stabbing. Diabetes, multiple sclerosis, chemotherapy drugs, injuries and amputations have all been associated with neuropathic pain, which is often chronic, sometimes unrelenting and affects millions of people worldwide. Many of the available pain medications are only moderately effective at treating this type of pain and often come with serious side effects, as well as risk of addiction…
The new compound, dubbed FEM-1689, does not engage opioid receptors in the body, making it a possible alternative to existing pain medications linked to addiction. In addition to reducing sensitivity, the compound can help regulate the integrated stress response (ISR), a network of cellular signaling that helps the body respond to injuries and diseases. When well regulated, the ISR restores balance and promotes healing. When it goes awry, the ISR can contribute to diseases such as cancer, diabetes and metabolic disorders…
“Significance- Neuropathic pain is a major medical problem that is poorly treated with existing therapeutics. Our findings demonstrate that targeting σ2R/TMEM97 with a modulator reduces pain hypersensitivity in a mouse model with exquisite selectivity.
We also identify integrated stress response (ISR) inhibition as a potential mechanism of action that links the receptor to cellular signaling events that have preclinical and clinical validation for pain relief. Our work suggests that σ2R/TMEM97 can be selectively engaged by specific small molecules to produce ISR inhibition in a subset of cells that are critical for neuropathic pain. σ2R/TMEM97-targeted therapeutics thus have the potential to offer effective pain relief without engagement of opioid receptors…
We and others have shown that σ2R/TMEM97 ligands alleviate mechanical hypersensitivity in mouse neuropathic pain models with a time course wherein maximal antinociceptive effect is approximately 24 h following dosing. We sought to understand this unique antineuropathic pain effect by addressing two key questions:
These results validate σ2R/TMEM97 as a promising target for further development for the treatment of neuropathic pain…
Management of neuropathic pain is a major clinical challenge because available drugs not only have limited efficacy, but they also elicit serious side effects…