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Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.

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Integrative Myeloma Therapies- Eliminate Chemo-induced Heart Damage

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“In patients receiving therapy for relapsed multiple myeloma, heart failure, angina, and other cardiovascular adverse events occurred more frequently with carfilzomib compared with bortezomib”

If you have been diagnosed with multiple myeloma you are going to experience short, long-term and late stage collateral damage aka side effects. Side effects are not the issue. The issue the MM patient must face is how to best manage the side effects he/she experiences. Consider integrative multiple myeloma therapies.

The article linked below explains that half of MMers who undergo carfilzomib (kyprolis) will experience heart damage within the the vast majority (86%) of patients experiencing their heart damage within the first three months of therapy.

At this point it is important for me to point out that it is more than likely that MMers experience heart damage that does not show up until long after active therapy has stopped. I developed chemotherapy-induced chronic atrial fibrillation about nine (9) years after my induction therapy and ASCT in 12/95.

My point is that the study linked below cites heart damage that occurs in the months immediately following chemotherapy. The MMer’s goal is to think long-term about his/her health. Integrative multiple myeloma therapy may prevent heart failure post MM chemotherapy.

Evidence-based but non-conventional therapies for reducing or eliminating heart damage run from

I am both a MM survivor and MM cancer coach. If you would like to learn more about integrative MM therapies to both increase the efficacy of conventional chemotherapy while reducing its toxicity, please scroll down the page, post a question or comment and I will reply to you ASAP.

Thank you,

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Cardiac Events More Common After Specific Therapy for Relapsed Multiple Myeloma

“In patients receiving therapy for relapsed multiple myeloma, heart failure, angina, and other cardiovascular adverse events occurred more frequently with carfilzomib compared with bortezomib, according to a study…

The observational, multi-institutional study followed 97 patients starting proteasome inhibitor therapy for relapsed multiple myeloma over a median 14 months: 65 patients received a chemotherapy regimen that included carfilzomib, and 32 patients received a regimen that included bortezomib…

In all, 61 cardiovascular adverse events occurred. Among evaluable patients, 50% receiving carfilzomib and 15% receiving bortezomib experienced at least one cardiovascular adverse event. The median time from treatment start to cardiovascular adverse event was 33 days, and 86% of all such events occurred within the first 3 months of treatment…

Coenzyme Q10 Cardioprotective Effects Against Doxorubicin-Induced Cardiotoxicity in Wistar Rat

“In the present study, we investigated the cardioprotective effects of coenzyme Q10 (Q10) against doxorubicin (DOXO) induced cardiomyopathy…

At the end of 14 days, systolic, diastolic and mean blood pressure, electrocardiogram (ECG), complete blood count, and serum biochemical profile were evaluated.

We also analyzed heart histological and ultrastructure analysis, and estimated heart’s oxidative stress and lipid peroxidation. DOXO administration altered ECG, with increase heart rate, P-wave duration, PR interval duration, and T-wave amplitude.

All the parameters were significantly reduced following Q10 treatment. DOXO also caused increase in CK, CK-MB, LDH, and urea levels, which were not mitigated by Q10 treatment.

However, Q10 reduced oxidative stress by interfering with superoxide dismutase, significantly decreasing lipid peroxidation in heart tissue.

DOXO administration also leads to several histological and ultrastructure alterations including cardiomyocyte degeneration and intense intracelullar autophagosomes, all minimized by Q10 treatment.

Q10 treatment prevented the ECG changes, minimized oxidative stress, lipid peroxidation, and DOXO-induced heart tissue alterations.

Our findings suggest that pre- and post-treatment with Q10 exerts potential cardioprotective effect against the DOX-induced cardiotoxicity.”

 

 

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7 comments
Chemo for High Risk Smoldering Myeloma- Pain... - PeopleBeatingCancer says 3 years ago

[…] Integrative Myeloma Therapies- Eliminate Chemo-induced Heart Damage […]

Reply
Kerry says 5 years ago

Hello I have come across your videos while doing research on multiple myeloma. My partner is currently undergoing tests for it. I want to be more informed but not sure I can afford your program. If you could please point me in the right direction. We are looking at integrative approaches alongside the conventional. Looking into essiac tea, curcumin, black seed oil, full spectrum cannabis oil he is currently using the cbd.
Want to know which of the conventional treatments he will need and how to counteract the damage. What supplements are recomended etc.
I understand you charge for this info but if you could just point me in the right direction it will be appreciated.
We dont know for sure but he has symptoms such as tiredness, breathlessness and pain in his lower back, he does have disk problems but this pain is different from his usual sciatica pain.
Warmest Regards.

Kerry

Reply
    David Emerson says 5 years ago

    Hi Kerry,

    Myeloma is often missed, as a diagnosis, if the M.D. isn’t looking for it. Be sure to get an accurate diagnosis. A couple of things. I will place a link to the MM Cancer Coaching page below. Further, you seem to be interested in evidence-based, non-conventional therapies that are apoptotic to MM as well as integrative therapies for MM chemotherapy regimens as well as complementary therapies.

    We are in the process of updating the MM Cancer Coaching program. I will send you this program at no charge because you are on the cusp so to speak.

    Multiple Myeloma Cancer Coaching Program-

    Let me know if you have any questions.

    David Emerson

    Reply
Carfilzomib-Induced Heart Damage in Multiple Myeloma - PeopleBeatingCancer says 5 years ago

[…] Integrative Myeloma Therapies to Reduce or Eliminate Chemo-induced Heart Damage […]

Reply
Carol Moore says 6 years ago

I had a MCI in 2004. Was 1st dx’d w/MM in 2003. 15 years later 12/218, I am in my 5th cycle of Kyprolis and Methylprednisolone. Is my MM using me as a trial? I was given a sheet explaining the cardio events to which I called Paramedics on 2 occasions. Prescribed Lisinopril 5mg , 1 then 2 now 3 daily. #’s great response. Not CR yet. Last cycle was a plateau. What should I do. I am 67. TY, TY – Carol

Reply
    David Emerson says 6 years ago

    Hi Carol,

    I’m not sure I can provide any clear directions. On the one hand, a MCI in ’04 may have damaged your heart. Yet on the other hand, living with MM for more than 15 years is well-beyond the averages. Yes, chemo regimens such as Kyprolis cause heart damage. Yet it also controls your MM. This is the type of decision that only you can make.

    Hang in there,

    David Emerson

    Reply
Cardiovascular Events in Multiple Myeloma Therapy - PeopleBeatingCancer says 6 years ago

[…] Kyprolis vs. Bortizomib heart damage in Multiple Myeloma […]

Reply
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