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MGUS to Myeloma- Obesity, Inflammation?

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“…based on 29 cases that progressed to MM or other LP diseases later in life, our study found midlife obesity to be a risk factor for progression among individuals diagnosed with MGUS.”

Hi David, I’ve been reading a lot about that study they did in 2016 about obesity creating a higher risk of Monoclonal Gammopathy of Undetermined Significance (MGUS) progressing to MM. I’m obese but I’ve lost 70lbs. I’ve got another hundred to go about.

My weight has fluctuated my whole life but I was only really heavy for the past 2.5 years. I was depressed and put it on very fast.


Can getting down to a healthy weight decrease my chances of progressing or is the damage done? I’m also eating the diet Dr. William Li recommends in his book which I’m reading now and I’m taking


  • Curcumin,
  • D3
  • K2,
  • Green tea Extract

and a bunch of other Standard Process supplements that I’ve taken forever OPC, Catalyn, Cardio Plus, Cyruta, and Omega-3 fatty acids.

I’m exercising daily and as I stated eating a super clean angiogenic diet. My spike is 0.3. Rudy

Hi Rudy- Your situation is coming into focus more clearly. If the study you are referring to is the same study that I read regarding MGUS and weight, my understanding is that excess weight puts the body in a state of constant inflammation. It is inflammation that increases the risk of MGUS progressing to frank or full blown MM.
The flip side of the MGUS/MM coin is the other risk reducing therapies such as
  • frequent, moderate exercise,
  • losing weight,
  • eating anti-angiogenic foods (I’m also reading “Eat to Beat Disease” by Dr. Li)
  • anti-MM supplementation (curcumin, D3, K2, green tea extract, omega-3 fast acids)
The other supplements you mention, such as cardio plus, are good for your heart health but I don’t know if the ingredients fall into the anti-inflammatory, anti-angiogenic category. I take cardio plus as well…
My thinking, as a long-term MM survivor, is that you are reducing your risks of progressing to MM. I do think you should continue loosing weight to continue to reduce your risks further.
I work with many MGUS and MM survivors who have low m-spikes for years. It is possible to manage a low m-spike, well, forever as far as i can tell. I consider the fact that because I have MM, I can relapse at any time. This possibility is my incentive to exercise frequently, supplement, eat angiogenic foods and supplements, detoxify regularly, etc.
I believe that living with this incentive helps me remain in complete remission. I hope you feel similarly.
I hope that makes sense. Let me know if you have any questions.
David Emerson
  • MM Survivor
  • MM Coach
  • Director PeopleBeatingCancer

Recommended Reading:

“We can reduce the inflammatory reaction by losing weight. Some people risk never getting rid of the inflammation. We have attempted to understand what is needed to reduce the inflammatory reaction without having to lose weight,” Halvorsen explains.

Unfortunately, storage of energy causes an inflammatory reaction. The explanation lies in the close connection between the body’s immune system, energy conversion and the way in which we store energy….”

Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based study

“Our results suggest that high BMI during midlife is associated with an increased risk of progression from MGUS/LC-MGUS to MM and other LP diseases later in life. This was not explained by known risk factors for progression. Previous studies have indicated that obesity might have a role in the etiology of MM.21,22,25,26

Recent pooled analysis of 20 prospective studies found that waist circumference is a risk factor for MM mortality and that BMI in early adulthood plays an important role in myelomagenesis.25

Additionally, on the basis of the available data, WHO recently concluded that there now is sufficient evidence behind the association between body fatness and MM.6

To date, only 1 study has examined the role of obesity in the progression of MGUS to MM. A study on a cohort of US veterans within the Veterans Health Administration system found an increased risk of MM to be associated with both overweight (HR, 1.55; 95% CI, 1.16-2.06) and obesity (HR, 1.98; 95% CI, 1.47-2.68) at MGUS diagnosis.42

We thus speculate that the observed risk of MM in individuals with obesity is not because of increased risk of MGUS, but rather that they have similar MGUS prevalence but a higher risk of progression…

In conclusion, in this Icelandic population-based cohort study, obesity is not associated with MGUS or LC-MGUS.

However, based on 29 cases that progressed to MM or other LP diseases later in life, our study found midlife obesity to be a risk factor for progression among individuals diagnosed with MGUS/LC-MGUS.

This study provides evidence that obesity might be the first modifiable risk factor for MGUS/LC-MGUS progression, but more studies, both large-scale population-based studies and clinical trials, are needed for better understanding of the etiology of MGUS/LC-MGUS and MM…”


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