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Multiple myeloma (MM) patients can undergo radiation for many reasons. During my four years of conventional therapies from ’94-’97 I underwent local radiation twice- first to “clean up” my original legion site and secondly to manage severe bone pain in anticipation of an ASCT.
I consider local radiation therapy to be the most useful conventional therapy for multiple myeloma-bar none. Yes, I live with serious long-term side effects from my radiation therapy but radiation bought me time to find an alternative therapy that put me into complete remission.
To be more specific, a myeloma patient might have a lesion in a bone or in his/her spine that can be causing pain and/or damage. Radiation can zap the lesion relieving the immediate concern.
The two challenges that all multiple myeloma patients face is that
In my case local radiation caused a long-term side-effect called radiation-induced limbo-sacral plexopathy (RILP). This is a fancy medical term for nerve damage. Radiation causes internal scarring. The scarring interferes with nerve function.
If you are a myeloma patient considering radiation therapy for any reason please read the studies linked and excerpted below.
Please watch the video below to learn more about the evidence-based, integrative therapies to combat treatment side effects and enhance your chemotherapy.
“Cancers will continue to be a threat to health unless they can be controlled by combinations of treatment modalities. In this review, evaluate the role of resveratrol (RSV) as a radiosensitizing agent was evaluated and underlying mechanisms holistically explored in different cancer models focusing on therapeutic possibilities.
The ability of RSV to modify the effect of radiation exposure in normal and cancer cells has indeed been shown quite convincingly, the combination of RSV and IR exhibiting synergistic effects on different cancer cells.
In general, it has been shown in different cancer cells that RSV+XRT effectively act by enhancing expression of anti-proliferative and pro-apoptotic molecules, and inhibiting pro-proliferative and anti-apoptotic molecules, leading to induction of apoptosis through various pathways, and cell death.
If RSV+XRT can suppress the signature of cancer stemness, enhance the radiosensitivity by either targeting the mitochondrial functionality or modulating the tumour necrosis factor-mediated or Fas-FasL-mediated pathways of apoptosis in different cancers, particularly in vivo, its therapeutic use in the control of cancers holds promise in the near future.”
“Late complications are one of the major factors limiting radiotherapy treatment, and their treatment is not codified. Hyperbaric oxygen (HBO) has been used in combination with radiotherapy for over half a century, either to maximise its effectiveness or in an attempt to treat late complications.
This updated literature review is part of the documents the jury based its opinion on. A systematic search was done on literature from 1960 to 2004, by only taking into account the articles that appeared in peer review journals.
Hyperbaric oxygen treatment involving complications to the head and neck, pelvis and nervous system, and the prevention of complications after surgery in irradiated tissues have been studied.
Despite the small number of controlled trials, it may be indicated for the treatment of mandibular osteoradionecrosis in combination with surgery, haemorrhagic cystitis resistant to conventional treatments and the prevention of osteoradionecrosis after dental extraction, whose level of evidence seems to be the most significant though randomised trials are still necessary. The other treatment methods are also outlined for each location.”