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Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission

Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.

Click the orange button to the right to learn more about what you can start doing today.

Synergize, Integrate w/ Velcade, Kyprolis, Ninlaro?

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The challenge for multiple myeloma survivors however, is that each proteasome inhibitor will stop working eventually. MDR aka multi-drug resistance is a fact for all multiple myeloma chemotherapy regimens.”

I received a multiple myeloma diagnosis in late 2015. I had a tumor on skull,  spine and hip. I had to have radiation therapy and chemo, then in may 2016 I had a bone marrow transplant. 

After that I refused all treatment and was good until may 2019 when my numbers were up again, took no treatment, but in dec 2019.

I underwent emergency surgery to remove a mass which was on my vertebrae pressing on my spinal column causing me some awful symptoms, was struggling to walk had no balance, right eye couldn’t see out of it and was struggling with bladder issues. 

The operation was only able to remove part of the mass, so I also had to undergo ten rounds of radiation, also had a mass on chest bone which was inoperable. 

After all of that we tried five different types of chemo to which I had horrible side affects. 

At the moment trying to go down a natural route, so any advise would be awesome and appreciated. 

I was an international swimmer so I try to swim a few miles every week.  Thanks for any help you can give. At the moment I am in remission  Joan


Hi Joan, 

I am sorry to read of all of the health challenges your MM has caused you. While you have certainly had to deal with your share of health problems caused by your MM, I read about similar health problems caused by-

  • multiple myeloma
  • chemotherapy
  • radiation, surgery

every day. 

To summarize your situation, after radiation, surgery and many different types of chemotherapy, you have experienced most every therapy that the F.D.A has approved for the treatment for multiple myeloma. 

The possible therapy plan for you going forward, in my experience anyway, is for you to combine conventional chemotherapy with those nutritional supplements that have been shown to enhance the efficacy of that chemotherapy. 

The word for this type of therapy is “integrative.” In your case I am talking about those therapies that research has shown can enhance proteasome inhibitors. 

Proteasome inhibitors have been shown to be effective against MM in their own right. The integrative application of this type of chemo has been shown to make the chemo more effective while managing some of the known side effects of these chemotherapy regimens. 

  • Bortezomib (Velcade), 
  • Carfilzomib (Kyprolis),
  • Ixazomib (Ninlaro),

Proteasome Inhibitors Show Promise as Treatment for Multiple Myeloma

“Three proteasome inhibitors (PIs) are approved for patients with multiple myeloma (MM): Bortezomib, a first-in class PI, fights both newly diagnosed and relapsed/refractory MM (RRMM); carfilzomib, a next-generation PI, treats RRMM as both a monotherapy and in combination; and ixazomib, the first oral PI, treats RRMM in combination…

Multiple Myeloma Chemotherapy- Proteasome Inhibitors-

“More importantly, a low concentration of RSV (resveratrol) was synergistic/integrative with a low dose of the proteasome inhibitor carfilzomib (CFZ) to induce apoptosis in myeloma cells…

Bortezomib (velcade), Carfilzomib (kyprolis) and Ixazomib (ninlaro) are all proteasome inhibitors. All three chemotherapy drugs are multiple myeloma chemotherapy regimens approved by the FDA.

The challenge for multiple myeloma survivors however, is that each proteasome inhibitor will stop working eventually. MDR aka multi-drug resistance is a fact for all multiple myeloma chemotherapy regimens.

If you are a MM patient or survivor who has undergone several multiple myeloma chemotherapy regimens already and is wondering about your next therapy steps, consider integrative therapies- combinations of conventional and non-conventional proteasome inhibitors that integrate or enhance each other…

While the solution, in my experience anyway, is evidence-based, it is not FDA approved. In other words, the studies linked below explain that

  • curcumin
  • omega-3 fatty acids
  • resveratrol
  • thymoquinone (black seed oil) and 
  • honokiol

all integrate with and enhance conventional MM protease inhibitors Bortezomib and Carfilzomib, but they are not FDA approved. This is why “non-conventional therapies” are called “non-conventional.” Because conventional oncology doesn’t study them and the FDA won’t approve them.

I can’t help but wonder if these non-conventional therapies also integrate with Ixazomib (ninlaro).”

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