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Early Stage Multiple Myeloma Diagnosis- Resveratrol? Pre-Habilitation?
“ Resveratrol inhibits the proliferation of MM cells by inducing apoptotic cell death. Resveratrol also inhibits MM cell invasion. The inhibition of invasion may be associated with…”
Hi David–I hope you are doing well. I’m feeling so-so. I have a question for you. When I first considered taking resveratrol for my early stage Multiple Myeloma diagnosis, I ran across the link below.
I also read your blog post on about Resveratrol and multiple myeloma.
Multiple Myeloma Therapy- Resveratrol
My questions are:
- is it the type and dose of resveratrol that matters?
- And–what about the brand or maker of the supplement?
And, should it be approached differently by those of us who have not started any kind of chemo vs post starting any kind of chemo?
I hope you do not mind sharing your personal opinion/views on this with me.
Hi N K.-
I will address each of your questions as best I can below. The fact that you have not begun any conventional therapies puts you in an ideal position to pre-habilitate– I will discuss this more below.
1) Yes, I supplement with resveratrol. I take a brand called Life Extension Optimized Resveratrol. I do so because it has been tested and approved by Consumerlab.com. Further, this formula of resveratrol contains other components that I think are beneficial to me.
- 200mg of trans resveratrol- yes, resveratrol has been shown to by cytotoxic to MM and can enhance the efficacy of Velcade. See the study linked below.
- 100mg of quercetin- also shown to be cytotoxic to MM and enhance dexamethasone.
- 25mg of blueberry extract- shown to be good for my brain…
The primary drawback, as I see it anyway, with resveratrol for MM patients, is the fact that high doses of resveratrol seem to have a negative effect on kidney function. The article you linked above mentions this. Before you supplement with resveratrol you should check your creatinine and BUN levels. Even though you are early stage MM, you may exhibit some kidney involvement.
My kidney function is fine though I supplement a low dose of resveratrol.
2) “What about the maker?” I discussed both the formulation of the resveratrol as well as the maker/brand I take. Both are important to me.
3) “should it be approached differently by those of us who have not started any kind of chemo vs post starting any kind of chemo?”
Yes, yes and yes. Let me explain. The post below about pre-habilitation in cancer is particularly important for multiple myeloma patients.
First and foremost, because MM is considered to be incurable, your goal is to get the most out of both conventional and non-conventional therapies as possible.
You can do this by doing everything you can do in an effort to enhance your treatment, your therapy plan. Maximizing all of your therapies is good for your prognosis. In other words, if you pre-habilitate and you can increase your survival and/or enhance your response to your induction therapy (whenever that occurs) and/or lengthen and deepen your response.
4) Lastly, please consider including additional evidence-based but non-toxic therapies to your pre-habilitation regimen. Curcumin, omega-3 fatty acids, exercise, WBH, etc. etc. according to studies will add to your pre-habilitation.
David Emerson
- MM Survivor
- MM Coach
- Director PeopleBeatingCancer
Recommended Reading:
- Multiple Myeloma Survival- Detox, Whole-Body Hyperthermia
- SMM Becoming Multiple Myeloma Diagnosis?
- Multiple Myeloma Diet- Organic vs. Conventional
Multiple Myeloma Pre-habilitation- Enhance Efficacy, Minimize Toxicity
“You have been diagnosed with multiple myeloma (MM), an incurable blood cancer. Your oncologist is promoting the standard-of-care treatment plan including induction therapy, an autologous stem cell transplant and low -dose mainteance therapy. These standard therapies are highly toxic, cause short, long-term side effects and may keep your MM at bay for only a year or two. What do you do?
Pre-habilitation…”
Resveratrol as a novel agent for treatment of multiple myeloma with matrix metalloproteinase inhibitory activity.
“RESULTS– Resveratrol inhibited proliferation of MM cells in a dose- and time-dependent manner. Incubation of MM cells with resveratrol resulted in apoptotic cell death.
Furthermore, resveratrol inhibited invasion of RPMI 8226, U266, and KM3 cells with IC50 values of 64+/-8 micromol/L, 93+/-11 micromol/L, and 153+/-11 micromol/L, respectively. Resveratrol inhibited the constitutive expression of MMP-2 and -9 proteins of MM cells and suppressed its gelatinolytic activity.
CONCLUSION: Resveratrol inhibits the proliferation of MM cells by inducing apoptotic cell death. Resveratrol also inhibits MM cell invasion. The inhibition of invasion may be associated with the attenuation of the enzymatic activities of MMP-2 and -9.
Quercetin Displays Anti-Myeloma Activity and Synergistic Effect with Dexamethasone in Vitro and In Vivo Xenograft Models
“Results: Quercetin inhibited proliferation of MM cells by inducing apoptosis and cell cycle arrest in the G0/G1 or G2 phase(quercetin group vs control,p<0.05)…
Quercetin also displays synergistic inhibition effect with dexamethasone in vitro (quercetin with dexamethasone vs quercetin only or dexamethasone only,p<0.05) and western blot confirmed these results. In vivo,tumor burdern of xenograft mice modeltreated by quercetin was significantly lower than those of control (quercetin group vs control,p<0.05).
Conclusions: Quercetin inhibits proliferation of MM cells by inducing apoptosis and cell cycle arrest in the G0/G1 or G2 phase through downregulating c-myc and cyclinD1 and upregulating p21 .Quercetin also displays synergistic inhibition effect with dexamethasone.Thus, quercetin combination with dexamethasone therapy may be an effective option for MM patients.