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Melanoma Therapy- Kills or Inhibits Melanoma Growth by 69% “Without Harming Healthy Cells”
In the study, the compound caused human melanoma cells to die and inhibited tumor growth by about 69 percent in a mouse model…
Normally, I never blog about therapies that “show promise” are “hopeful” or are anything other than results based on research. I am breaking my rule because of the cancer, melanoma, (mel) that is the cancer being studied. Not only is mel an incredibly aggressive disease but it has taken two of my best friends in their twenties. Melanoma is personal.
Equally as important, when a cancer therapy kills a cancer cells “without harming nearby healthy cells” I admit that I take notice. I live with long-term and late stage side effects from the conventional therapies that I underwent when I was first diagnosed. As the saying goes, “the cure is worse than the disease.”
Have you been diagnosed with melanoma? As a cancer survivor and cancer coach I can research clinical trials testing NISC-6. Scroll down the page, post a question or comment and I will reply to you ASAP.
In the meantime please consider supplementing with cruciferous vegetables. I take a Standard Process – Cruciferous Complete because if the anti-cancer action of naturally occurring isothiocyanates.
Thank you,
David Emerson
- Cancer Survivor
- Cancer Coach
- Director PeopleBeatingCancer
Compound shows promise in treating melanoma
“While past attempts to treat melanoma failed to meet expectations, an international team of researchers are hopeful that a compound they tested on both mice and on human cells in a petri dish takes a positive step toward creating a drug that can kill melanoma cancer cells without harming nearby healthy cells…
In the study, the compound caused human melanoma cells to die and inhibited tumor growth by about 69 percent in a mouse model…
The isoselenocynate moiety was designed based on naturally occurring isothiocyanates, which can be found in vegetables, such as broccoli and cauliflower, and are known for their cancer prevention properties…
“There are a lot of recommendations that, for example, broccoli can reduce your chances of getting cancer,” said Sharma. “Those are OK recommendations for prevention, but the compounds in the vegetables alone may not be potent enough to be used in a therapeutic environment.”
To improve the effectiveness, the researchers modified the drug by replacing the sulfur in a compound they studied earlier with selenium, as well as varying the length of the alkyl chain to create isoselenocynate. Several variations were screened before the researchers arrived at a compound that they thought could kill the cancer cells without increasing toxicity levels…
Sharma said NISC-6 may also work on other forms of cancer, which will likely be included in future research…”
Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity.
“Furthermore, NISC-6 effectively induced apoptosis in human melanoma cells, inhibited tumor growth by ∼69% in a melanoma mouse xenograft model, and showed excellent compliance with the Lipinski’ rule of five, suggesting both its efficacy and drug-like behavior under physiological conditions…”