Learn how you can stall the development of full-blown Multiple Myeloma with evidence-based nutritional and supplementation therapies.
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“A rare inherited gene mutation predisposes people to developing a form of blood cancer called multiple myeloma, according to a new study by a multicenter research team led by Weill Cornell Medicine scientists.
The paper, published March 20 in Cancer Research, found that people with a mutation in a gene called lysine (K)-specific demethylase 1A, or KDM1A, had 6 to 9 times the risk of developing multiple myeloma.
The research allows doctors to identify patients who are more likely to develop the disease, so that they can receive ongoing monitoring and treatment earlier in the course of disease, which correlates with better patient outcomes…”
“Symptoms- People with monoclonal gammopathy generally don’t experience signs or symptoms. Some people may experience a rash or nerve problems, such as numbness or tingling. MGUS is usually detected by chance when you have a blood test for another condition…”
“Multiple myeloma (MM) and its precursor, monoclonal gammopathy of undetermined significance (MGUS), have been linked with several autoimmune conditions in the medical literature. Yet, significance of these associations is not well understood…
Findings-Scientific literature on autoimmune conditions in patients with MM and MGUS consists of several case series and a multitude of case reports. Our analysis suggests an increased prevalence of autoimmune conditions in patients with MM and monoclonal gammopathy of undetermined significance (MGUS), including various autoimmune hematologic and rheumatologic conditions among other entities. Conversely, persons with various autoimmune conditions tend to have a higher prevalence of MGUS and MM than the general population.
Conclusions- Future research is required to explore further the link between MGUS/MM and autoimmune disorders. Inflammation in the setting of autoimmunitymay serve as a trigger for MGUS and MM.
In addition, a common genetic susceptibility for developing both an autoimmune disease and MM/MGUS might also exist.
Autoimmune hematologic and rheumatologic diseases may pose important clinical problems for the MM patients.
Therefore, a catalogue of these problems is important so that physicians are able to consider, identify and address them promptly.