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PeopleBeatingCancer

Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission

Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.

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Myeloma Genetics, Epigentics- Turn on, turn off…

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“Many small molecules targeting regulators of epigenetic machinery have been developed and clinical trials are underway for some of these in MM.”

The first study linked and excerpted below talks about “regulators of epigenetic machinery” in multiple myeloma (MM). The researchers and I both agree with the idea of epigenetic machinery but we approach the therapies to change the multiple myeloma genetics (genetic expression of MM) of patients and survivors differently.

The researchers look for drugs while I follow people such as Dr. Dean Ornish and his research into the epigenetics of prostate cancer.

“We found that simple changes have a powerful impact on gene expression.”

Those 12 words spoken by Dr. Dean Ornish are the foundation of my own approach to managing my health. Though the study that Dr. Ornish refers to is about prostate cancer and not my cancer multiple myeloma, when I read this study years ago the basic ideas made so much sense to me that I adopted the basic tenets of Dr. Ornish’s study:

  • intensive diet (much reduced intake of meat and fats,much higher intake of fruits, vegetables, and whole grains, supplemented with soy, fish oil, selenium and vitamins C and E-
  • physical exercise
  • stress-reduction intervention,
  • the men walked or worked out for 30 minutes six times a week
  • did yoga stretches, breathing and meditation sessions for an hour every day,
  • and every week they also took part in one hour group support sessions.

Or to put it another way, our genes may predispose us to multiple myeloma but MM is not our fate. Once someone is diagnosed with MM the way to cure oneself of MM is to change how his/her genes express themselves. At least this has been my approach to managing my own incurable blood cancer.

Conventional oncology’s myeloma therapies do a poor job of managing our cancer. Consider thinking outside the conventional box-

The phrases linked below indicate some of the greatest potential in cancer care today. I think conventional drugs that are developed as a result of molecular diagnostics and cancer genomics are years away from impacting current cancer survivors (me). So I choose to focus on Dr. Dean Ornish and what he has shown.

For information about multiple myeloma, scroll down the page, post a question or comment and I will reply ASAP.

Thank you,

David Emerson

  • Multiple Myeloma Survivor,
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma.

“Next generation sequencing and large-scale analysis of patient specimens has created a more complete picture of multiple myeloma (MM) revealing that epigenetic deregulation is a prominent factor in MM pathogenesis.

RECENT FINDINGS: Over half of MM patients have mutations in genes encoding epigenetic modifier enzymes. The DNA methylation profile of MM is related to the stage of the disease and certain classes of mutations in epigenetic modifiers are more prevalent upon disease relapse, suggesting a role in disease progression. Many small molecules targeting regulators of epigenetic machinery have been developed and clinical trials are underway for some of these in MM.

SUMMARY: Recent findings suggest that epigenetic targeting drugs could be an important strategy to cure MM. Combining these agents along with other strategies to affect the MM cell such as immunomodulatory drugs and proteasome inhibitors may enhance efficacy of combination regimens in MM.

Complex grammar of the genomic language

“The ‘grammar’ of the human genetic code is more complex than that of even the most intricately constructed spoken languages in the world. The findings explain why the human genome is so difficult to decipher — and contribute to the further understanding of how genetic differences affect the risk of developing diseases on an individual level…

The genome contains all the information needed to build and maintain an organism, but it also holds the details of an individual’s risk of developing common diseases such as diabetes, heart disease and cancer…

The sequencing of the human genome in the year 2000 revealed how the 3 billion letters of A, C, G and T, that the human genome consists of, are ordered. However, knowing just the order of the letters is not sufficient for translating the genomic discoveries into medical benefits; one also needs to understand what the sequences of letters mean. In other words, it is necessary to identify the ‘words’ and the ‘grammar’ of the language of the genome…

Each gene has a regulatory region that contains the instructions controlling when and where the gene is expressed…

Our study identified many such words, increasing the understanding of how genes are regulated both in normal development and cancer,” says Arttu Jolma. “The results pave the way for cracking the genetic code that controls the expression of genes.”

Epigenetics: A New Bridge between Nutrition and Health

“Nutrients can reverse or change epigenetic phenomena such as DNA methylation and histone modifications, thereby modifying the expression of critical genes associated with physiologic and pathologic processes, including embryonic development, aging, and carcinogenesis.

It appears that nutrients and bioactive food components can influence epigenetic phenomena either by directly inhibiting enzymes that catalyze DNA methylation or histone modifications, or by altering the availability of substrates necessary for those enzymatic reactions.

In this regard, nutritional epigenetics has been viewed as an attractive tool to prevent pediatric developmental diseases and cancer as well as to delay aging-associated processes.

In recent years, epigenetics has become an emerging issue in a broad range of diseases such as type 2 diabetes mellitus, obesity, inflammation, and neurocognitive disorders. Although the possibility of developing a treatment or discovering preventative measures of these diseases is exciting, current knowledge in nutritional epigenetics is limited, and further studies are needed to expand the available resources and better understand the use of nutrients or bioactive food components for maintaining our health and preventing diseases through modifiable epigenetic mechanisms…”

 

 

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11 comments
Myeloma- Gene Regulation as Therapy - PeopleBeatingCancer says 8 months ago

[…] To Learn More about cancer genetics and epigenetic- click now Thank you, David Emerson […]

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Epigenomic Changes Slow Melanoma - PeopleBeatingCancer says 8 months ago

[…] To Learn More about cancer genetics and epigenetic- click now […]

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Myeloma- Lifestyle- Nutrition, Exercise - PeopleBeatingCancer says 8 months ago

[…] To Learn More about cancer genetics and epigenetic- click now […]

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Myeloma, Cancer, Genetic Markers, Risk - PeopleBeatingCancer says 8 months ago

[…] To Learn More about cancer genetics and epigenetic- click now […]

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Multiple Myeloma Diagnosis- Epigenetics &Your Genes - PeopleBeatingCancer says 8 months ago

[…] To Learn More about cancer genetics and epigenetic- click now […]

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Change Genetic Expression in Cancer says 8 years ago

[…] to https://peoplebeatingcancercoaching.org Let me know if you have any questions. David Emerson Cancer Genes- Turn on, turn off… ‹ Prostate Cancer Therapy Posted in non-conventional therapies, nutrition Tagged with: […]

Reply
Leslie says 8 years ago

My husband has a 3 cm tumor in his colon that has been diagnosed as malignant. Nothing more now. Vitamin C & E will be added. He is 78 years and very active training horses.

Reply
    David Emerson says 8 years ago

    Hi Leslie-

    I am sorry to learn of your husband’s colon cancer diagnosis. A 3 cm tumor is quite small. Please get a second opinion to confirm malignancy and stage as staging directly relates to the therapy plan and prognosis (chemo, radiation and outlook).

    Colon Cancer staging slide show- see slide #10

    When you say “nothing more now” I take you to mean that there is no therapy, surgery or otherwise, planned at this stage?

    There are several antioxidant, non-toxic supplements that studies have show are cytotoxic (kills) to colon cancer. If you are interested I can provide both the studies for your review- I take low doses of many of the same supplements for my own cancer.

    Let me know if you are interested and if there is any information I can provide.

    thanks and hang in there

    David Emerson

    Reply
Caryn Anderton says 8 years ago

Another suggestion would be learning everything you can about your Myeloma. They call it Multiple Myeloma for a reason– What sub-type do you have? What is your genomic risk? There is a test MyPRS that gives you all of this information and information is key in decision making.

GOOD Luck and God Bless

Reply
Scott says 8 years ago

Hello, my name is Scott, I’m 44 and was dx’d with MM in July 2015. Scans revealed many bone lesions, blood and urine had high levels of free light chains. Bone marrow biopsy showed lots of plasma cells. I just finished four cycles of CRD and was told by my oncologist yesterday that I achieved complete remission. Although there is no evidence of residual disease in my blood, urine, or bone marrow, the plan is to continue on with the auto transplant in late Nov/early Dec. I’ve been trying to find research that would suggest whether or not a “wait and see” approach is reasonable since there is no evidence of any disease remaining. I would be interested to hear your thoughts on this or if you’ve seen research on this? Thank you for your time!

Reply
    David Emerson says 8 years ago

    Hi Scott-

    I am sorry to read of your MM though I will offer congratulations for reaching complete remission. You are correct to wonder if aggressive therapy in the form of an auto SCT in a few weeks is the right path for you. Though I have an opinion I will try to present both sides of the issue below.

    Pro SCT-

    1) Your onc. will tell you that you have the best chance for a deep, long remission by reaching CR with induction therapy (CRD) and then hitting your MM again with an ASCT.

    Pro Wait and See-

    1) An ASCT is aggressive, toxic therapy. Collateral damage aka side effects- short, long-term and late stage side effects are well documented and even your onc. has to admit that collateral damage will occur.

    2) There is disease still hiding inside you. This is why all MMers relapse. Well, not everyone. The article/study that you came in on, the study conducted by Dr. Dean Ornish leads me to believe that MM can only be cured by changing our genetic expression.

    Please keep in mind that while my reasoning has been verified for prostate cancer, it has NOT been verified for MM.

    3) There are a host of non-conventional, non-toxic therapies that are evidence-based, aka supported by research, that are cytotoxic to MM cells. I have been doing these therapies for years. If you are interested I can present those studies that pushed me to do what I do.

    4) Lastly, and perhaps most importantly, there is no reason for you to have an ASCT immediately. The reason given by conventional oncology will be that high-dose chemotherapy (ASCT) will work best when the MM cell load is lowest in your body. Though I have never found a study that supports that reasoning.

    The research I can present is 1) non-conventional therapies that kill MM yet are non-toxic. 2) A link to info about the one conventional oncologist, Dr. James Berenson, who advocates a “control” rather than a “cure” approach to MM.

    I will link info to Dr. Berenson below. I am not advocating that you see Dr. Berenson unless you live near LA. I am linking info about him to educate you about his approach.

    James Berenson

    Let me know if you have any questions. Let me know if you would like info, studies about nonconventional MM therapies- studies, brands, doses, etc.

    thanks and hang in there

    David Emerson

    Reply
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