fbpx

Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission

Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.

Click the orange button to the right to learn more about what you can start doing today.

Multiple Myeloma Genetics, Epigentics- Turn on, turn off…

Share Button

“Many small molecules targeting regulators of epigenetic machinery have been developed and clinical trials are underway for some of these in MM.”

The first study linked and excerpted below talks about “regulators of epigenetic machinery” in multiple myeloma (MM). The researchers and I both agree with the idea of epigenetic machinery but we approach the therapies to change the multiple myeloma genetics (genetic expression of MM) of patients and survivors differently.

The researchers look for drugs while I follow people such as Dr. Dean Ornish and his research into the epigenetics of prostate cancer.

“We found that simple changes have a powerful impact on gene expression.”

Those 12 words spoken by Dr. Dean Ornish are the foundation of my own approach to managing my health. Though the study that Dr. Ornish refers to is about prostate cancer and not my cancer multiple myeloma, when I read this study years ago the basic ideas made so much sense to me that I adopted the basic tenets of Dr. Ornish’s study:

  • intensive diet (much reduced intake of meat and fats,much higher intake of fruits, vegetables, and whole grains, supplemented with soyfish oil, selenium and vitamins C and E-
  • physical exercise
  • stress-reduction intervention,
  • the men walked or worked out for 30 minutes six times a week
  • did yoga stretches, breathing and meditation sessions for an hour every day,
  • and every week they also took part in one hour group support sessions.

Or to put it another way, our genes may predispose us to multiple myeloma but MM is not our fate. Once someone is diagnosed with MM the way to cure oneself of MM is to change how his/her genes express themselves. At least this has been my approach to managing my own incurable blood cancer.

The phrases linked below indicate some of the greatest potential in cancer care today. I think conventional drugs that are developed as a result of molecular diagnostics and cancer genomics are years away from impacting current cancer survivors (me). So I choose to focus on Dr. Dean Ornish and what he has shown.

For information about multiple myeloma, scroll down the page, post a question or comment and I will reply ASAP.

Thank you,

David Emerson

  • Multiple Myeloma Survivor,
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:


Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma.

“Next generation sequencing and large-scale analysis of patient specimens has created a more complete picture of multiple myeloma (MM) revealing that epigenetic deregulation is a prominent factor in MM pathogenesis.

RECENT FINDINGS: Over half of MM patients have mutations in genes encoding epigenetic modifier enzymes. The DNA methylation profile of MM is related to the stage of the disease and certain classes of mutations in epigenetic modifiers are more prevalent upon disease relapse, suggesting a role in disease progression. Many small molecules targeting regulators of epigenetic machinery have been developed and clinical trials are underway for some of these in MM.

SUMMARY: Recent findings suggest that epigenetic targeting drugs could be an important strategy to cure MM. Combining these agents along with other strategies to affect the MM cell such as immunomodulatory drugs and proteasome inhibitors may enhance efficacy of combination regimens in MM.

Complex grammar of the genomic language

“The ‘grammar’ of the human genetic code is more complex than that of even the most intricately constructed spoken languages in the world. The findings explain why the human genome is so difficult to decipher — and contribute to the further understanding of how genetic differences affect the risk of developing diseases on an individual level

The genome contains all the information needed to build and maintain an organism, but it also holds the details of an individual’s risk of developing common diseases such as diabetes, heart disease and cancer

The sequencing of the human genome in the year 2000 revealed how the 3 billion letters of A, C, G and T, that the human genome consists of, are ordered. However, knowing just the order of the letters is not sufficient for translating the genomic discoveries into medical benefits; one also needs to understand what the sequences of letters mean. In other words, it is necessary to identify the ‘words’ and the ‘grammar’ of the language of the genome

Each gene has a regulatory region that contains the instructions controlling when and where the gene is expressed

Our study identified many such words, increasing the understanding of how genes are regulated both in normal development and cancer,” says Arttu Jolma. “The results pave the way for cracking the genetic code that controls the expression of genes.”

 

 

Leave a Comment:

6 comments
Add Your Reply