Hi David- I’m Roz 34 from Vancouver. Diagnose sept 17 at estimated stage 2 and by the time I underwent a 10hr surgery dec 4 I was discovered to be stage 4. partial glosectomy dissection and resection, left neck dissection, left forearm free flap.
I will be starting treatment next week and am very anxious. I’m at British Columbia cancer agency which I’ve hear great things about. Unfortunately they said they majority of the patients they’ve had with my cancer are male and in the 60s.
So, severity of side effects for me I get a 50/50 only bc they really don’t know. I’m a rare case… I’m a
All they say is genetics and bad luck. I kinda feel like a Guinea pig, then dr’s aren’t making me feel that way … But I know that my case may set a precedent for future cases. Was hoping to hear if you have found anything that is similar to my case.
Hope to talk soon- Roz
“Cancers will continue to be a threat to health unless they can be controlled by combinations of treatment modalities. In this review, evaluate the role of resveratrol (RSV) as a radiosensitizing agent was evaluated and underlying mechanisms holistically explored in different cancer models focusing on therapeutic possibilities.
The ability of RSV to modify the effect of radiation exposure in normal and cancer cells has indeed been shown quite convincingly, the combination of RSV and IR exhibiting synergistic effects on different cancer cells.
This is relevant since controlled exposure to IR is one of the most frequently applied treatments in cancer patients. However, radiotherapy (XRT) treatment regimes are very often not effective in clinical practice as observed in patients with
for example, largely due to tumour radioresistant properties. Sensitization of IR-induced apoptosis by natural products such as RSV is likely to be relevant in cancer control and treatment. However, all cancers do not respond to RSV+IR in a similar manner.
Therefore, for those such as the radioresistant PCa or melanoma cells, the RSV+IR regime has to be very carefully chosen in order to achieve effective and desirable outcomes with minimum toxicity to normal cells. They are reports that the highest concentration of 100 ?M RSV and highest dose of 5 Gy IR are sufficient to kill cells by induction of apoptosis, indicating that RSV is effective in radiosensitizing otherwise radioresistant cells.
In general, it has been shown in different cancer cells that RSV+XRT effectively act by enhancing expression of anti-proliferative and pro-apoptotic molecules, and inhibiting pro-proliferative and anti-apoptotic molecules, leading to induction of apoptosis through various pathways, and cell death. If RSV+XRT can suppress the signature of cancer stemness, enhance the radiosensitivity by either targeting the mitochondrial functionality or modulating the tumour necrosis factor-mediated or Fas-FasL-mediated pathways of apoptosis in different cancers, particularly in vivo, its therapeutic use in the control of cancers holds promise in the near future.”