Minimal Residual Disease (MRD) in Multiple Myeloma

“Overall survival was favorable among MRD-negative patients, as well as among patients with complete response.”

After 25 years and reading 000’s of studies, I’m cynical when it comes to conventional oncology and what they recommend about treating multiple myeloma. If an oncologist examined 21 studies and all they can come up with is/are words like favorable or associated with then minimal residual disease is no breakthrough.

If you are a newly diagnosed patient CR and MRD is certainly your goal for both your induction therapy as well as your autologous stem cell transplant should you decide to undergo this side-effect filled, toxic, grueling procedure. But I think that the MMers health and QOL must be balanced with the pursuit of either CR or MRD-negative status.

I am a long-term MM survivor and MM cancer coach. I read the study below two ways. Does reaching minimal residual disease (MRD) lead to longer overall survival in multiple myeloma no matter how much damage you do with chemotherapy?

Or are some types of myeloma prone to reaching MRD? Are their types of MM that are easier to kill than others? Could you reach minimal residual disease after having a short course of induction therapy?

Further, are their evidence-based therapies that are cytotoxic to myeloma that are non-toxic? Are their evidence-based therapies that can enhance the efficacy of conventional chemotherapy regimens?

Yes and Yes. There are therapies that can integrate with conventional (FDA approved) chemotherapy. Combine RVD, for example, with evidence-based, non-toxic, anti-MM therapies such as supplementation, nutrition, bone health, lifestyle and mind-body therapies and your remission will be deeper, longer than it would with chemotherapy alone.

Please watch the video below to learn more about the evidence-based, integrative therapies to combat treatment side effects and enhance your chemotherapy.

Have you been diagnosed with MM? Are you thinking about an autologous stem cell transplant (ASCT)?

Please scroll down the page, post a question or comment and I will reply to you ASAP.

Whether you are debating treatment options, currently undergoing treatment and experiencing painful side effects, or trying to figure out how to stay in remission, I want to share what I’ve learned from 25 plus years of full remission from Multiple Myeloma.

Click now to learn more about Minimal Residual Disease in Multiple Myeloma-

thank you,

David Emerson

MM Survivor
MM Cancer Coach
Director PeopleBeatingCancer

MRD-negative Status Linked With Better Survival in Multiple Myeloma

“Minimal residual disease (MRD)-negative status among patients with newly-diagnosed multiple myeloma after treatment may be associated with long-term survival, according to a study published in JAMA Oncology.¹

Researchers led by Nikhil Munshi, MD, of the Dana-Farber Cancer Institute in Boston, MA, evaluated 21 studies through Medline, which provided data on the impact of MRD status on progression-free and overall survival.

Information on patient characteristics, treatment, MRD assessment, and outcomes, were gathered. Data were adjusted to allow for different proportions of patients with MRD across the studies.

There were 12 studies with data on impact of MRD on overall survival, and 14 for progression-free survival. MRD-negative status was associated with better progression-free survival, particularly in studies of patients who had achieved conventional complete response.

Overall survival was favorable among MRD-negative patients, as well as among patients with complete response.”

Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission

Minimal Residual Disease (MRD) in Multiple Myeloma

“Overall survival was favorable among MRD-negative patients, as well as among patients with complete response.”

Recommended Reading:

MRD-negative Status Linked With Better Survival in Multiple Myeloma

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