These results showed that C-B-D by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death…These data provide a rationale for using C-B-D to increase the activity of proteasome inhibitors in MM.
Dear Cancer Coach-I’ve Just been diagnosed with myeloma multiple. Big shock as I went in to hospital with a bad back and came out with incurable cancer.
I live on the island of Tenerife where C-B-D oil is legal. I have started on the oil along with other natural resources. I really do not want chemotherapy, but should I have it in conjunction with the oil. Paul
Hi Paul-
I am sorry to learn of your MM diagnosis. Depending on your stage and blood work however, a person can live with MM for a long time and hopefully die of old age. Several things.
C-B-D oil has been shown to integrate with two MM chemotherapy regimens- I don’t know if carfilzomib is covered by the NHS but I’m pretty sure bortezomib (velcade) is. I understand that you said that you would prefer not to undergo chemotherapy. Taking a non-toxic approach is difficult with MM and depends on your age, stage at diagnosis, symptoms, etc. Also, C-B-D has been shown to stregthen bones.
Research of C-B-D and MM is limited but some studies indicate that C-B-D is cytotoxic to MM by itself. The degree of cytotoxicity depends on the cannabinoid content in the C-B-D oil you are taking. It depends on how high the percentage of cannabinoids is.
Further, there are a number of non-toxic antioxidants such as curcumin and resveratrol that also integrate or synergize with different chemotherapies. Keep in mind that curcumin is difficult for the body to absorb. Please scroll down the page to learn about more bioavailable curcumin formulas. I will email a list to of integrative theraies to your email address.
Do you know your stage of MM? Your m-spike? Blood testing is common for MM. It is important to know your serum calcium, creatinine, red blood cells, white blood cells, etc.
Are you experiencing any other symptoms? Do any other bones hurt?
My approach or my experience anyway, is to combine evidence-based non-toxic therapies with as little toxic therapies as possible. As an aside, I take a dozen or so drops of Charlotte’s Web C-B-D oil before bed every night.
David Emerson
- Cancer Survivor
- Cancer Coach
- Director PeopleBeatingCancer
The Most BioAvailable Curcumin Formulas
“Based on a review of these studies, it is evident that better bioavailability of formulated curcumin (CU) products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism”
A search of the Pubmed database for the word curcumin yields 601 studies spaning health topics from multiple myeloma and colorectal cancer, to chemotherapies that synergizes with CU, to Alzheimer’s Disease, arthritis and more. Based on years of reading studies and personal accounts, I think it is safe to say that CU supplementation is safe and relatively inexpensive.
I have read about myeloma patients taking daily doses of CU from 400 milligrams to 8 grams (1000 milligrams = 1 gram). By almost any measure, CU is a safe, inexpensive wonder drug.
The only challenge is that CU is famously difficult to absorb in the body. In other words, a person has to mix curcumin with some sort of fat (coconut oil, chocolate, etc.) or take a brand of curcumin capsule that is already formulated to be more “bioavailable” in order to derive the full benefit of CU.
The study linked and exerpted below reviews different formulations of CU. The study itself lists the three most bioavailable formulation/brand of CU and I’ve added an excerpt from a further review from Consumerlab.com that lists four additional bioavailable brands of CU.
I consult the independent evaluation service Consumerlab.com frequently. For one low annual payment, I can read about and evaluate all of the nutritional supplement that I take.
Recommended Reading:
“CU is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.[1]“
Curcumin is synergistic in the same way C-B-D oil is.
“Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native CU is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability.
The purpose of this review is to collate the published clinical studies of CU products with improved bioavailability over conventional (unformulated) CU. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinetics data were included in this review. Further, the data on clinical study design, analytical method, pharmacokinetic parameters and other relevant details of each formulation were extracted.
Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations.
Based on the published reports,
exhibited over 100-fold higher bioavailability relative to reference unformulated CU. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed.”
According to Consumerlab.com:
“Novasol has the highest bioavailability (185 x compared to unforumulated CU), followed by Curcuwin (136 x), Longvida (100 x), Meriva (48 x), BCM-95 (27 x), Curcumin C3 Complex + Bioperene (20 x), and then Theracumin (16 x).”
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