Curcumin Suppresses Colon Cancer, Enhances Chemotherapy

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According to the studies below, curcumin suppresses colon cancer, enhances the effects of  5-FU and oxaliplatin and can even protect against 5-Fu toxicity

Conventional oncology can do many amazing things for cancer patients. Unfortunately, conventional oncology cannot prescribe any therapy that has not been evaluated and approved by the Food and Drug Administration (FDA). This fact forces the colon cancer patient to think a bit outside the oncology box.

I am a cancer survivor and cancer coach. My bias is not about FDA approvals but therapies that can help the cancer patient. If you have been diagnosed with colon cancer, let me ask you:

  • If you could enhance the efficacy of your chemotherapy with an inexpensive, non-toxic supplement
  • If this same supplement also was shown to inhibit colon cancer,
  • Finally, if this supplement was also shown to reduce the toxicity of chemotherapy

would you add this supplement to your regimen? Would you supplement with curcumin even if your oncologist didn’t approve? I will be honest with you. I had a difficult time doing things that my oncologist didn’t like. I was forced to form my own opinions on my health only after my oncologist told me “there is nothing more I can do for you…”

 

I take Life Extension Super BioCurcumin. I supplement with this brand of curcumin because it has been evaluated for purity and efficacy an approved by Consumerlab.com and independent testing service. I supplement with a formula of curcumin that has been shown to be more than six time more “bioavailable” than regular curcumin.

Have you been diagnosed with colon cancer? What stage? Please scroll down the page, post a question or comment and I will reply to you ASAP.

Thank you,

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Curcumin and Doxorubicin Combo in Relapsed/Refractory Multiple Myeloma


Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF-κB, uPA activator and MMP9.

“The present study investigated the hypothesis that curcumin inhibits colon cancer cell invasion by modulating NF-κB-mediated expression and activation of uPA and MMP9…

. Overall, the present data suggest that curcumin inhibits colon cancer cell invasion via AMPK activation and subsequent inhibition of p65 NF-κB, uPA and MMP9…”

Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R.

“Curcumin (diferuloylmethane), which has been shown to inhibit growth of transformed cells, has no discernible toxicity and achieves high levels in colonic mucosa. 5-fluorouracil (5-FU) or 5-FU plus oxaliplatin (FOLFOX) remains the backbone of colorectal cancerchemotherapeutics, but with limited success

Indeed, results of our in vitro studies demonstrated that curcumin together with FOLFOX produced a significantly greater inhibition of growth and stimulated apoptosis  of colon cancer HCT-116 and HT-29 cells than that caused by curcumin, 5-FU, curcumin + 5-FU or FOLFOX

We also suggest that inclusion of curcumin to the conventional chemotherapeutic agent(s)/regimen could be an effective therapeutic strategy for colorectal cancer.”

Curcumin reduces cytotoxicity of 5-Fluorouracil treatment in human breast cancer cells.

“5-Fluorouracil (5-FU), an antimetabolite that inhibits cell proliferation, has served an important role in standard chemotherapy protocols for a variety of solid tumors. Although reasonable response rates have been reported for 5-FU, continued exploration is necessary to improve clinical outcomes and reduce cytotoxic side effects that are an inherent problem for chemotherapeutic interventions

When 5-FU incubations were repeated with the addition of curcumin, the LD50 value increased to 200-300 μM, representing a 7-10-fold protection by curcumin against 5-FU cytotoxicity. These findings suggest that the addition of curcumin as an adjuvant therapy during 5-FU treatment might enhance the chemotherapeutic effectiveness of 5-FU by protecting normal cells from reduced viability and thus permitting higher dosing or longer treatment times….”

 

 

 

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