Learn how you can manage and alleviate your current side effects while actively working to prevent a relapse or secondary cancer using evidence-based, non-toxic therapies.
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Chemotherapy-induced liver damage is not about the type of cancer you have but the type of FDA approved “safe and effective” therapy you are prescribed. And, according to the first two studies linked and excerpted below there is a long and growing list of regimens that can cause chemotherapy-induced liver damage.
While you probably won’t die from chemotherapy-induced liver damage, you may very well sustain long-term damage to your liver function as is outlined in the last study linked below.
If you are fortunate enough to be reading this post after your cancer diagnosis but before you have begin undergoing chemotherapy then you need to pre-habilitate with one or more of the evidence-based non-conventional therapies listed below shown to protect the liver from chemotherapy-induced liver damage.
If you have already undergone chemo and you have already sustained liver damage (such as two of the posts linked below) your choices are to discuss a therapy vacation/break with your oncologist giving your liver a chance to heal and/or undergo the of the hepto-protective therapies such as milk thistle shown to protect liver health.
Chemotherapy-induced liver damage surprisingly common yet treatable with evidence-based non-conventional therapies-
Diagnostic tests that look at liver function include:
Have you been diagnosed with chemotherapy-induced liver damage? Are your bilirubin levels out of the normal range? Scroll down the page, post a question or a comment and I will reply to you ASAP.
Hang in there,
“Hepatotoxicity of chemotherapeutic agents such as
have been well documented and characterized allowing for careful management by oncologists during administration. However, the rapid advance of the field of oncology and introduction of new classes of therapies such as small molecule inhibitors and immunotherapies have introduced new hepatotoxicity challenges and management strategies…”
“A wide variety of drugs exhibit hepatotoxicity that must be monitored for including, but not limited to, drugs such as
Additionally, conventional chemotherapeutic agents have well characterized hepatotoxic effects with some of the most common identified agents including methotrexate, irinotecan, and oxaliplatin . Hepatotoxicity related to administration of chemotherapeutic agents includes
Agents that have been shown to cause increased hepatotoxicity in conjunction with radiation therapy include
Classes of chemotherapies that cause hepatotoxicity include-
The rest of this review will place more focus on the hepatotoxicity of new classes of anticancer therapies. These targeted agents include:
Chemotherapy typically induces cellular damage that results in impaired cell division or apoptosis of rapidly dividing cells. The nonselective characteristics of traditional chemotherapeutic agents result in off target adverse effects including, but not limited to, hepatotoxicity…
“Many chemotherapy medications rely onTrusted Source the liver for metabolization. However, some can cause severe liver damage. Chemotherapy medications may causeTrusted Source mild liver problems, and combination therapies can worsen these effects…
Curcumin- Palipoch et al. (2014) found that curcumin pretreatment could decrease liver lipid peroxidation and NADPH oxidase expression in cisplatin-treated rats to prevent cisplatin-associated liver damage. Curcumin is also proven to protect mitochondria from chemotherapy-induced oxidative stress…”
Omega-3 fatty Acids- “In the many, large, randomized controlled trials of the omega-3 fatty acids, side effects have been minimal. Use of omega-3 fatty acids even in high doses has not been linked convincingly to serum enzyme elevations or to instances of clinically apparent liver injury…”
“Conditions such as SOS, steatosis, pseudocirrhosis, and even hepatic necrosis can occur as a direct result of chemotherapy, which may simulate a clinical presentation of long term hepatic damage and cirrhosis…”