Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission

Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.

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Lytic Lesions- Can Multiple Myeloma Patients Heal Bone Damage?

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“Myeloma cells disturb a normally balanced bone remodeling process. This imbalance of bone metabolism may cause osteopenic bones, focal osteo lytic lesions and clinical symptoms.”

For the MM patient, bone involvement is both a symptom and a side effect. Multiple myeloma causes bone damage from thinning bones to little holes in the bones to big holes (think Swiss cheese). We MM patients want to know how to heal our MM as well as how to heal our lytic lesions aka out bone damage. How do MM patients and survivors manage our bone health? How do we heal our bones?

According to the research linked below, MM patients can heal their bones sometimes. According to my experience as a MM survivor, yes, we can heal our bones completely.

The difference between a conventional therapy’s “maybe” and a non-conventional therapy’s “yes” is the difference between how the FDA has to do things and how a multiple myeloma survivor like me does things.

Please note that I am not criticizing the FDA here. I’m simply saying that I/we have a lot more flexibility in the therapies that we undergo.

FDA “Standard-of-care” bone therapies are:

  • bisphosphonates (acedia, pamidronate, etc.) and
  • denosumab

Evidence-based but not FDA approved bone therapies are:

  • Supplementation (vitamin d3, curcumin, resveratrol, DHEA, etc.)
  • Exercise,
  • Nutrition,
  • As well as the standard-of-care therapies

I was non-secretory. My MM didn’t exhibit much in my blood or urine. But I experienced lots of bone involvement. Think big “swiss cheese-like” holes. When I was told I was end-stage, I was walking around with more than a dozen holes in my bones.

I was thankful when a non-conventional therapy put me into complete remission after 17 months of therapy. However I did worry about my bone health going forward. I wondered if I would experience bone breaks…

My point is that over the next half-dozen years, I worked at all the non-conventional bone health therapies listed above and my bones healed. Completely.

I believe that multiple myeloma survivors must always work to stay in remission as well as work to maintain their bone health. Yes, this is a sort of double burden of MM survivorship but I think by living this way, you will be happier and healthier.

Have you been diagnosed with MM? Are you experiencing a lot of “bone involvement?” To learn more about both conventional and non-c0nventional bone therapies scroll down the page, post a question or a comment and I will reply to you ASAP.

Hang in there,

David Emerson

  • MM Survivor
  • MM Coach
  • Director PeopleBeatingCancer 

Recommended Reading:

Multiple Myeloma Pain

NCI Dictionary of Cancer Terms

“Lytic lesion (LIH-tik LEE-zhun) Destruction of an area of bone due to a disease process, such as cancer”

Bone healing in multiple myeloma: a prospective evaluation of the impact of first-line anti-myeloma treatment

“Myeloma cells disturb a normally balanced bone remodeling process. This imbalance of bone metabolism may cause osteopenic bones, focal osteolytic lesions and clinical symptoms.

The excess bone resorption resulting in osteolytic lesions has traditionally been perceived as irreversible. We investigated the potential for bone healing in a prospective study of previously untreated multiple myeloma (MM) patients using a five-drug bortezomib-containing treatment regimen…

Well-defined osteo lytic lesions with a diameter of ≥10 mm on CT-scans were identified as target lesions at baseline. Each target lesion was then evaluated in terms of size and development of osteosclerosis in all consecutive CT-scans. The presence of osteosclerosis at the edge of a target lesion was interpreted as an early sign of healing and classified dichotomously as being either present or not present (Figure 1).

More pronounced formation of sclerotic bone, together with a simultaneous reduction in the largest diameter of the osteolytic lesion by ≥30%, was interpreted as a more advanced sign of healing (Figure 1)…

In addressing the impact of a five-drug bortezomib-containing treatment on bone healing in MM, we found development of a rim of sclerosis in the osteolytic lesions of the majority of the patients and that some osteolytic lesions also showed more profound signs of healing. While sclerosis was observed in all the lesions in a small number of patients, a heterogeneous response was found in individual patients in general, with some lesions showing sclerosis or healing and some showing no response…

This prospective study showed that osteolytic lesions may, at the very least, be partially reversible in the majority of responding patients. Nevertheless, our data also showed intra-patient variation with respect to re-induction of bone formation in the osteolytic lesions. As a consequence, the degree of destruction of the microenvironment within the individual osteolytic lesion may have implications for any possibility of achieving healing of bone lesions…”




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