If you’ve been diagnosed with multiple myeloma (MM), you’ve been told that this blood cancer is incurable but very treatable. A long and growing list of FDA approved chemotherapy regimens kill your MM for a time, but the MM almost always relapses. Consider the non-conventional, evidence-based multiple myeloma therapy called thymoquinone.
Chemotherapy regimens such as bortezomib (Velcade) and cyclophophomide (Cytoxan) can kill MM but often cause short, long-term and late stage side effects to the patient. I underwent two courses of high-dose Cytoxan in September of 1995 and my bladder hasn’t been the same since.
What if you could supplement with an evidence-based therapy that would kill your MM, enhance the efficacy of Velcade and/or Cytoxan and heal your body from the ravages caused by the chemo? Consider evidence-based therapies such as thymoquinone that can integrative with conventional therapies.
This is too good to be true, right? Maybe not.
Thymoquinone has been shown to modulate nine out of the ten hallmarks of cancer. Experts are urging more research into thymoquinone, which is the active main constituent in black seed oil, for adjuvants to pharmaceutical cancer treatments, and signalling pathways that black cumin seed oils play in being a cancer killer…
Many studies have shown the effects of Nigella sativa on various different cancer cells, and the list is long offering up over 57 reviewed papers on the subject finding black cumin to be effective against cancers such as blood, breast, colon, pancreatic, lung, leukemia, skin, fibrosarcoma, renal, prostate, and cervical cancer.
Anticancer effects are mediated through different modes of action including cell cycle arrest, apoptosis induction, ROS generation and anti-metastasis/anti-angiogenesis, and anti-proliferation…
Black cumin has been shown to be provide effective protection against the toxicity of the drug cyclophosphamide, suggesting administration of NSO of TQ can lower CTX induced toxicity by upregulation of antioxidant mechanisms, indicating potential to minimise toxic effects of treatment with anticancer drugs.
Nigella sativa oil has been recommended as a natural radioprotective agent against immunosuppressive and oxidative effects of ionizing radiation…
“Thus in the present study, we investigated whether thymoquinone (TQ), a bioactive constituent of black seed oil, could suppress the proliferation and induce chemosensitization in human myeloma cells and xenograft mouse model. Our results show that TQ inhibited the proliferation of MM cells irrespective of their sensitivity to doxorubicin, melphalan or bortezomib. Interestingly, TQ treatment also resulted in a significant inhibition in the proliferation of CD138+ cells isolated from MM patient samples in a concentration dependent manner…
Overall, our results demonstrate that TQ can enhance the anticancer activity of bortezomib in vitro and in vivo and may have a substantial potential in the treatment of MM.”
“Treatment with anticancer drugs such as cyclophosphamide (CTX) is associated with significant toxicity due to over-production of reactive oxygen species..
Twenty-four hours after the last NSO and TQ treatment, blood and liver were harvested to analyse toxicity-related parameters. Treatment with CTX induced significant toxicity as shown by decrease in haemoglobin concentration and increases in blood sugar levels, activities of liver enzymes, bilirubin, urea, creatinine, lipids (triglyceride, cholesterol and low-density lipoprotein (LDL)-cholesterol) and lipid peroxidation in the liver.
Treatment with NSO or TQ induced significant reduction in overall toxicity. The antitoxic effects of NSO and TQ were associated with induction of antioxidant mechanisms. These results suggest that administration of NSO or TQ can lower CTX-induced toxicity as shown by an up-regulation of antioxidant mechanisms, indicating a potential clinical application for these agents to minimise the toxic effects of treatment with anticancer drugs.”
Multiple MyelomaTherapy- Thymoquinone both Cytotoxic and Integrative
“In the present report, we investigated whether thymoquinone (TQ), the main component isolated from the medicinal plant Nigella sativa, modulated the STAT3 signalling pathway in MM cells…”
Living with multiple myeloma (MM) since 2/1994 has taught me one clear truth. Depending on type and stage of your MM, conventional multiple myeloma therapies aren’t enough for the majority of multiple myeloma patients, survivors and caregivers. Don’t take my word for it, ask your oncologist if the multiple myeloma therapy that he/she is recommending to manage your MM is curative. It isn’t.
Thymoquinone (TQ) is an example of a non-conventional, evidence-based, non-toxic therapy that kills several types of cancer by itself and can enhance the efficacy of bortezomib/velcade as the studies linked and excerpted show. The studies below cite thymoquinone as a cytotoxic to multiple myeloma and can enhance the efficacy of chemotherapy to MM.
Further, an anti-angiogenic diet, intravenous vitamin C therapy and frequent, moderate exercise are all well-documented complementary therapies for the MM patient or survivor.
I recommend Herbal Secrets Black Seed Oil Natural Dietary Supplement- This brand of thymoquinone is well-reviewed on Amazon and is their best seller.
Recommended Reading:
“In the present report, we investigated whether thymoquinone (TQ), the main component isolated from the medicinal plant Nigella sativa, modulated the STAT3 signalling pathway in MM cells…
TQ also significantly potentiated the apoptotic effects of thalidomide and bortezomib in MM cells.
CONCLUSIONS AND IMPLICATIONS-
Our study has identified STAT3 signalling as a target of TQ and has thus raised its potential application in the prevention and treatment of MM and other cancers…
“Multiple myeloma (MM) is a B cell malignancy characterized by clonal proliferation of plasma cells in the bone marrow. With the advent of novel targeted agents, the median survival rate has increased to 5 -7 years.
However, majority of patients with myeloma suffer relapse or develop chemoresistance to existing therapeutic agents. Thus, there is a need to develop novel alternative therapies for the treatment of MM.
Thus in the present study, we investigated whether thymoquinone (TQ), a bioactive constituent of black seed oil, could suppress the proliferation and induce chemosensitization in human myeloma cells and xenograft mouse model. Our results show that TQ inhibited the proliferation of MM cells irrespective of their sensitivity to doxorubicin, melphalan or bortezomib…
TQ also potentiated the apoptotic effects of bortezomib in various MM cell lines through the activation of caspase-3, resulting in the cleavage of PARP.
Overall, our results demonstrate that TQ can enhance the anticancer activity of bortezomib in vitro and in vivo and may have a substantial potential in the treatment of MM…”
“Exposure of cells derived from lung (LNM35), liver (HepG2), colon (HT29), melanoma (MDA-MB-435), and breast (MDA-MB-231 and MCF-7) tumors to increasing TQ concentrations resulted in a significant inhibition of viability through the inhibition of Akt phosphorylation leading to DNA damage and activation of the mitochondrial-signaling proapoptotic pathway…
In view of the available experimental findings, we contend that thymoquinone and/or its analogues may have clinical potential as an anticancer agent alone or in combination with chemotherapeutic drugs such as cisplatin.”
