Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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MGUS, SMM and Stage 1 MM are treated differently than stage 3 MM. Research and personal experience has taught me that multiple myeloma patients and survivors must use the best of both conventional (FDA) therapies as well as the best of non-conventional MM therapies.
While there is a long and growing list of FDA approved chemotherapy regimens for MM such as Velcade and Carfilzomib (kyprolis), there are evidence-based, “integrative therapies” for MM that have been shown to enhance the efficacy of chemo while reducing the risk of side effects.
Cannabidiol or CBD is an integrative multiple myeloma therapy. The question is should you use CBD for bone marrow cancer aka multiple myeloma? If so, what dose? Is C-B-D effective at fighting multiple myeloma?
Though research is sparse, studies to confirm:
Cannabidiol is one of many evidence-based, non-conventional MM therapies shown to be cytotoxic to MM, and shown to integrate with MM chemotherapies such as Velcade, Revlimid, Cytoxan, Melphalan and Dexamethasone.
This blog post is a compilation of topics and studies about MM and C-B-D that I have collected over the years. MM patients frequently ask me about efficacy, uses, dosing, strains, etc.
I am happy to email you a digital copy of the cannabis guide if you email me at David.PeopleBeatingCancer@gmail.com.
“And while CBD does have tangible benefits, there are still a lot of questions about side effects and how much you should be taking…
There are no federal oversights or regulations on CBD products or their labeling. Meaning it’s hard to know how much CBD is actually in the product you buy. In fact, up to 70% of CBD products you buy on the internet either have more or less CBD than listed on the label…
What can you use CBD for?
Research, though limited, indicates that CBD has legitimate health benefits. While there is no FDA regulation, research has shown that full-spectrum and broad-spectrum CBD effectively treat and anxiety. There’s only one FDA-approved CBD product, called Epidiolex, that’s available by prescription. Epidiolex treats seizure disorders such as Lennox-Gastaut syndrome and Dravet syndrome…
Oils and tinctures
CBD oils generally come in either a liquid or capsule form. You can take the extracts independently or use the dropper to add them to food or drinks. Liquid tinctures are usually taken directly under the tongue.
“Tinctures are generally taken at higher concentrations than oils. This means that if you were taking 1 milliliter of tincture, you would need to drop the concentration down to 0.5 milliliters. A good rule of thumb is to start with a small dose (0.25 milliliters) and slowly increase your dose over time,” says Reda Elmardi, a registered dietician and certified nutritionist…
Edible CBD products are quickly becoming very popular, likely because of their convenience and flavor profiles. With edibles, you have several options in flavor, potency and prices. They have everything, from gummies to cookies, chocolates and even granola bars.
CBD is also available in topical creams and salves applied directly to the skin. Popular forms are lotions, creams or ointments. Topical CBD products are good options for muscle pains, joint inflammation or nerve pain.
Topical CBD is one of the more difficult forms for determining dosage. Not only does potency vary by product, but also varies by how much you use each application. It’s important to follow manufacturer instructions carefully…
How to determine the best dosage for you
CBD products express dosage in milligrams. Epidiolex starts with a dosage of 2.5 milligrams taken twice a day. After a week, you can increase the dosage to 5 milligrams twice a day. Federal regulation makes determining dosage straightforward.
For the rest of the products on the market not regulated by the FDA, there are no established guidelines for CBD concentration, which makes determining how much you should take a little more difficult. There are a few key factors you need to keep in mind — your weight, what you’re treating and the concentration of the product.
The ideal dosage for you will vary depending on what you’re using it for and what form you’re taking. Don’t forget that different forms also mean how quickly it takes effect. Generally, edibles, oils and capsules will take roughly 30 to 60 minutes to take effect. Smoking or vaping CBD will bring it on significantly quicker since the CBD absorbs into your bloodstream rather than your digestive system.
CBD dosage will vary by condition
In general, the dosage is dependent on the disease and its ability to be managed by CBD. The research that is available on CBD treatments has very varied dosage levels. Clinical studies have varied in oral doses from 100 to 800 milligrams a day. Others administer lower levels around 40 milligrams. A 2019 study investigating anxiety found that 300 to 600 milligrams of CBD reduced anxiety symptoms. However, that study was limited to 57 adult males.
“For generalized anxiety or sleep disorders, 25 to 75 milligrams per day is recommended, while for PTSD, 33 to 50 milligrams per day is recommended. In severe anxiety, a patient’s dose might be increased to 300 to 600 milligrams. If the patient is experiencing pain due to chemotherapy, 50 to 60 milligrams is recommended, with a maximum daily dose of 600 milligrams,” says Kimberly Langdon, a board-certified MD.
How much CBD is best for you will depend on your body. Your body weight and existing medications will influence the ideal dosage for you…
Can you take too much CBD?
A clinical review of studies confirmed that people tolerate doses as high as 1,500 milligrams a day. We want to stress that the research around CBD dosage is still really young, so there is not much to point to about how much is too much for people. More research is needed to definitively conclude the ideal dosage for each condition.
Not a ton of known side effects associated with CBD products. Though fatigue, diarrhea and appetite changes have been reported. The FDA states that CBD can cause liver damage and potentially impact the other prescription medications you’re taking.
If you’re starting your CBD journey, it’s best to slowly build your dosage so you can monitor how it affects you…
“But the characteristic that causes C-B-D (cannabinoids) to stand out, particularly in the mainstream media, is that it produces none of the psychoactive “high” effects for which T-H-C is famous…”
“These results showed that CBD by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death by regulating the ERK, AKT and NF-κB pathways with major effects in TRPV2+ cells. These data provide a rationale for using CBD to increase the activity of proteasome inhibitors in MM.”
“Cannabidiol, a non-psychotropic component of marijuana, may enhance the healing process of bone fissures, according to a new study…
We found that CBD alone makes bones stronger during healing, enhancing the maturation of the collagenous matrix, which provides the basis for new mineralization of bone tissue. After being treated with CBD, the healed bone will be harder to break in the future.“”
“Cannabinoids may offer significant “side benefits” beyond analgesia. These include anti-emetic effects, well established with THC, but additionally demonstrated for CBD (Pertwee 2005), the ability of THC and CBD to produce apoptosis in malignant cells and inhibit cancer-induced angiogenesis (Kogan 2005; Ligresti et al 2006), as well as the neuroprotective antioxidant properties of the two substances (Hampson et al 1998), and improvements in symptomatic insomnia (Russo et al 2007)…”
…we also found that the CBD and THC combination is able to reduce expression of the β5i subunit as well as to act in synergy with Carfilzomib (CFZ) to increase MM cell death…
A myeloma diagnosis results in induction therapy (perhaps RVd), MM remission, an autologous stem cell transplant, and another, hopefully, deeper MM remission. While research has never confirmed that ASCT provides a longer overall survival (OS), research does demonstrate that the average PFS or remission is longer with an ASCT.
But now you are coming out of remission…does this mean that you are running out of therapy options? Am I nearer to the end than the beginning? Conventional wisdom says that your next remission will be shorter than your first. Just as important, you have suffered several short, long-term and late stage side effects. You are tired of the side effects that come from chemotherapy.
So what’s a relapsed/refractory MMer to do? Your oncologist is suggesting carfilzomib but you’ve heard about the difficult toxicity and side effects of this chemotherapy regimen.
According to the two studies linked and excerpted below, CBD and curcumin act synergistically to both enhance the MM killing action of CFZ as well as reduce the toxicity of CFZ. But maybe you are wondering if either/or of these integrative therapies can interfere with the efficacy of carfilzomib.
To quote “this combination (CBD and CFZ) exerts strong anti-MM activities” and “curcumin can ameliorate carfilzomib efficacy…”
To be fair, the studies below are “in vitro” meaning they take place in a test tube. No pharmaceutical company in existance is going to test a unpatentable product like curcumin or CBD in human beings. To a large extent, myeloma patients and survivors are on their own in the latter stages of their incurable disease.
“Herein, we also found that the CBD and THC combination is able to reduce expression of the β5i subunit as well as to act in synergy with Carfilzomib (CFZ) to increase MM cell death and inhibits cell migration. In summary, these results proved that this combination exerts strong anti-myeloma activities…
In multiple myeloma, our previous findings demonstrated that CBD reduced cell proliferation and induced necrotic cell death . In the present study, our data on THC and mainly on the THC-CBD combination as stimulatory factors of autophagic-dependent cell death in MM cell lines, support previous data regarding the efficacy of cannabinoids as anti-tumoral drugs, in different human cancer models.
For cannabinoids, different experimental data suggested that the combined administration of cannabinoids with other anti-cancer drugs, could act synergistically, to reduce tumor growth and chemoresistance...
In MM cells, the CBD and Bortezomib (BTZ) combination was found to be more effective compared with BTZ alone and to act synergistically in inducing cell death .
Herein we investigated the effect of CBD and THC in combination with CFZ, showing a synergistic effect between the three drugs, supporting the fact that combining THC-CBD with established cytotoxic agents should result in a higher level of anticancer activity compared with that of cytotoxic agents acting alone…
Therefore, a combination therapy including cannabinoids and chemotherapeutic drugs could allow the reduction of chemotherapeutical doses administered in patients, without affecting the antitumoral therapy...