Diagnosed with SMM, SPB, or MGUS?

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Elevated IGG, no M-spike, Dx of MGUS- Thoughts?

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“The risk of (MGUS) progression to multiple myeloma or related disorders (in 115 patients) at 20 years with an initial monoclonal protein value of 1.5 g per deciliter was 1.9 times the risk of progression with an initial value of 0.5 g per deciliter or less…”

I had an IFE test (immunofixation electrophoresis) which showed elevated IgG at 2585. IgA & IgM were within normal range. Bone marrow biopsy test & Bence Jones test were done also. Bone marrow shows Kappa-Clonal plasma cells at 5%.

The 24-hour urine test shows no monoclonal proteins. My diagnosis is MGUS. Kappa light chain free is 29.7 (3.3-19.4) & Kappa/Lambda ratio is 2.52 (0.26-1.65). Red blood hemoglobin & hematocrit at very low end of normal range.

What supplements should I be taking to prevent full-blown myeloma Anything that has worked for you or someone else would be welcome. I am 84 years old & in good health otherwise.)

Thank you & God bless you, Rich

Hi Rich-

I’m sorry you’ve had trouble reaching me. Based on my experience you are low even for pre-myeloma or MGUS. Technically you are IGG kappa but again, very early.

At 83 and in otherwise good health I will guess that any slight MM is low risk and slow moving. I work with 93-year-old MGUS patient who has managed to keep his m-spike under one by supplementing with curcumin.

I think Mort takes one capsule daily (400 mg), maybe one in the am and one in the pm. Life Extension Super Bio-Curcumin

Adding anti-angiogenic foods and curcumin to your daily diet is an evidence-based but non-toxic way to reduce your risk of a MM diagnosis.

Let me know if you have any other questions.

Hang in there,

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Long-term follow-up of curcumin treated MGUS/SMM patients – an updated single centre experience

“Multiple myeloma (MM) evolves through a spectrum of disease from a premalignant stage of monoclonal gammopathy of undetermined significance (MGUS)

  • serum M-protein value of <30 g/L,
  • bone marrow plasma cells <10%,
  • no or small amount of M-protein in the urine, and
  • absence of lytic bone lesions, anemia, hypercalcemia, or renal insufficiency

to an intermediate stage of smoldering multiple myeloma (SMM)

  • serum M protein level >30 g/L and/or bone marrow plasma cells >10%,
  • plus no anaemia, hypercalcemia, renal failure, or lytic bone lesions

and finally presents with symptoms and signs of end-organ damage which leads to the diagnosis of MM [1]. Studies indicate that almost all cases of MM are preceded by the precursor state of MGUS or SMM [2]…

Based on its antimyeloma cell activity, we have performed a number of studies with curcumin in MGUS/SMM patients, including a randomised, double-blind placebo- controlled cross-over study, published in the American Journal of Hematology [7] where we showed that treatment of MGUS/SMM patients with curcumin resulted in an improvement in markers of disease progression (i.e., free light-chain ratio (rFLC), paraprotein levels, percentage plasma cells) in some patients [8].

A number of patients who participated in our studies and who showed a benefit, have continued to take curcumin over a number of years, of their own volition, even though the studies in which they were participating are complete…”

The State of the Science on Anti-Angiogenic Foods

“As tumors grow, they often build blood vessels that connect to the body’s circulatory system. The vessels provide conduit for nutrients that tumors need to continue their expansion. Drugs that block the process of blood-vessel creation, known as angiogenesis, have been approved to treat certain types of colon, lung, and breast tumors, as well as other cancers.

Research suggests that compounds found in certain foods, such as green tea, red grapes, kale, and artichokes may also inhibit angiogenesis. But that doesn’t mean such foods are a substitute or replacement for prescribed therapies, according to Dana-Farber Cancer Institute nutritionist Stacy Kennedy, MPH, RD, CSO, LDN

A healthy diet, such as the one Kennedy describes, can provide a range of benefits for cancer patients, potentially by helping to reduce inflammation and manage common side effects of treatment, such as constipation and fatigue. The possibility that some of these foods may also interfere with tumor angiogenesis could be an additional motivation for including them in one’s diet, but should not be a person’s sole motivation for eating a plant-heavy diet, Kennedy emphasizes.

Concrete answers to whether foods with angiogenic-blocking compounds can actually benefit patients may emerge from studies like one recently launched by Harvard University, in which investigators are exploring whether patients who respond better to treatment than expected have certain dietary, environmental, or attitudinal aspects in common…”


Leave a Comment:

Carolyn says a couple of years ago

I would like for you to contact me. I was told had elevated M proteins about 8 years ago. In the last 2 years I have had symptoms but I am still running into doctors who to make me think I am crazy. What should be my next step?

    David Emerson says a couple of years ago

    Hi Carolyn-

    Before we talk, let’s cover the basics of your situation. Do you know your level of M proteins aka your m-spike? I ask because you could live normally with an m-spike of less than 1 for years. A formal diagnosis of multiple myeloma is an m-spike of 3.0. Less than that is pre-mm.

    Most importantly, pre-multiple myeloma, where I think you may be, is considered to be a “blood disorder.” Not cancer. As such, conventional oncology does not offer any therapies. Most pre-mm patients are told to watch and wait.

    Do you know any other diagnostic testing information such as your Freelight chains- kappa, lambda and K/L ratio?

    let me know, thanks.

    David Emerson

Misdiagnosis, Dr. James Berenson, Stage 1 Multiple Myeloma - PeopleBeatingCancer says a couple of years ago

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