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Diagnosed with SMM, SPB, or MGUS?

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Diagnostic Testing for MGUS

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Whether you “watch and wait” or undergo non-toxic MGUS therapies, regular diagnostic testing is now a part of your life

You’ve been diagnosed with monoclonal gammopathy of undetermined significance (MGUS) and you are trying to wrap your brain around this diagnosis. It is an asymptomatic “blood disorder” yet it can become a full-blown diagnosis of an incurable blood cancer called multiple myeloma.

My experience as a long-term MM survivor is that the more you the patient, learn about your diagnosis,  the more in control you will become.

This may sound odd but from my perspective  you are in a kind of a cancer sweet spot. By this I mean that your diagnosis should motivate you to make an effort to remain PRE-MM. And you can be certain you are pre-MM or MGUS only through diagnostic testing your blood, marrow and bones.

MGUS at a glance-

Frankly, regular testing is a small price to pay considering the downside risks of your monoclonal gammopathy of undetermined significance becoming Multiple Myeloma. The diagnostic testing linked below will  explanation of some of the tests you will have short and/or long term.

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If you do not want to “watch and wait” to see if your pre-MM progresse to Multiple Myeloma scroll down the page, post a question or a comment and I will reply to you ASAP.

Consider monoclonal gammopathy of undetermined significance therapies such as:

  • non-toxic, cytotoxic/apoptotic supplements,
  • foods that starve MGUS/SMM and MM
  • evidence-based mind-body therapies,
  • detoxification therapies,
  • Non-conventional bone health therapies

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Blood-

“MGUS is usually detected during blood tests for another condition, such as a certain nerve disorder (peripheral neuropathy). The blood tests can show abnormal proteins as well as unusual amounts of normal proteins. If your doctor detects monoclonal gammopathy, further testing may be recommended to determine which M protein your body is making and how much is being made…”

Serum Protein Electrophoresis 

“Serum protein electrophoresis (SPEP) is an easy, inexpensive method of separating proteins based on their net charge, size, and shape…”

Serum free light-chain measurement

“Immunoglobulin light chains that are circulating in serum in a free (unbound) state are called free light chains (FLCs). Measurement of the serum level of FLCs became practical as a clinical blood test in recent decades..”

Imaging tests

“Multiple myeloma is the most common primary malignant neoplasm of the skeletal system. The disease is a malignancy of plasma cells. Clinical definitions of the various myeloma subtypes have been updated as have the imaging definitions of what constitutes bone marrow disease and individual bony involvement..”

Bone Marrow Biopsy

“Our findings suggest that reports on bone biopsies should include in addition to the number of plasma cells, the pattern of plasma cell infiltration and the presence or absence of multiple lymphoid nodules…”

 

Leave a Comment:

33 comments
Katrina wahl says 9 months ago

I was diagnosed with MGUS in the last 6 weeks. I am trying to figure out the best diet and supplements to prevent progression. Thank you

Reply
    David Emerson says 9 months ago

    Hi Katrina-

    Have you been told your “risk?” Do you know your m-spike or have you had a bone marrow biopsy? In general, a Meditteranean diet with primarily fruits and veggies can reduce your risk of progression. Further, curcumin, omega-3 fatty acids, green tea extract and resveratrol also will reduce your risk of progression.

    The more information you can provide the more input I can provide.

    Let me know.

    David Emerson

    Reply
      Katrina wahl says 9 months ago

      Thank you for responding. I had a M spike of 0.2 and then 2 more blood tests that couldn’t find another quantifiable M spike. My bone marrow showed monoclonal plasma cell neoplasm with <5%. Remainder of results were normal. IGG kappa band on serum protein electrophoresis.

      Reply
Raul Holguin says 11 months ago

My 87 years old father was recently diagnosed with MGUS after a trip to the ER for a very rapid onses allergic reaction which was diagnose as Alpha-gal syndrome so now all red meats are out of his diet. I would like to know more about your nutrition guide. Thanks

Reply
    David Emerson says 11 months ago

    Hi Raul-

    I am sorry to read of your dad’s MGUS diagnosis. Depending on your father’s diagnostic testing information, he may be low-risk and therefore unlikely to develop full MM.

    Further, evidence-based non-conventional pre-MM (MGUS) therapies such as nutrition, supplementation, and lifestyle therapies can reduce his risk of not only MM but a host of other age-related chronic diseases.

    Do you know any of his other diagnostic results such as a BMB or freelight chain assay?

    Hang in there,

    David Emerson

    Reply
Kristin says last year

Hello. I’m looking for diet information as well. I’m newly diagnosed with MGUS. I’m 39 and healthy except for anemia iron deficiency. I’m looking to keep this away for a long time because I have 4 kids to life for. Any help is greatly appreciated. Gratefully -Kristin Dowty

Reply
    David Emerson says last year

    Hi Kristin-

    I sent you the MM CC nutrition guide via email.

    Good luck,

    David Emerson

    Reply
Ken says last year

MGUS for 1-1/2yrs, what are test result levels that indicate move from MGUS to smoldering Meyloma.

Reply
    David Emerson says last year

    Hi Ken-

    Oncologists think about progression differently sometimes but in general the diagnostic tests that point to progression are

    Freelight Chain Kappa/Lambda ratio-
    M-spike
    Monoclonal proteins IN your bone marrow (the percentage)
    and CRAB symptoms

    Let me know if you have any questions.

    David Emerson

    Reply
Pre- Myeloma Diagnosis - SPB, MGUS, SMM - PeopleBeatingCancer says last year

[…] Diagnostic Testing for MGUS […]

Reply
Bruce says a couple of years ago

Interested to know your diet. I’m simply on whole food, all natural and organic. No sugar, no processed foods (it’s always a struggle, though).

Reply
    David Emerson says a couple of years ago

    Hi Bruce-

    I sent the MM CC nutrition guide to you via email. If it isn’t in your in box please check your spam folder.

    David Emerson

    Reply
MGUS Diagnosis - PeopleBeatingCancer says a couple of years ago

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Norman says 3 years ago

I have had mgus for four yrs now , what is the mgus food diet you have mentioned that helps .

Reply
    David Emerson says 3 years ago

    Hi Norman-

    I replied to you directly via email.

    David Emerson

    Reply
      Norman says a couple of years ago

      Thank you David , been under the weather lately ,

      Reply
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Rose Jamal says 7 years ago

Hi, my monoclonal peak identified as IgG Kappa 5.0 g/L. Rest of the tests are normal. Will Reservatrol help to not develop to MM? Need your advice.

Reply
    David Emerson says 7 years ago

    Hi Rose-

    Just to make sure, when you say “monoclonal peak” you are referring to your monoclonal protein commonly referred to as your “m-spike?” If you have an m-spike of 5.0 and if you have no other symptoms (CRAB) aka bone, kidney, etc. then you are probably stage 1. Yes studies show that resveritrol is cytotoxic (kills) to MM. However my guess is that your oncologist will recommend that you begin induction therapy. Probably a triplet called RVd or revlimid, velcade and dexamethasone.

    If you intend to undergo induction therapy then you may achieve a longer, deeper remission by taking resveritrol in addition to other integrative MM therapies. You can enhance the efficacy of revlimid, velcade and dex. with other evidence-based non-toxic therapies by doing so. Probably reduce your risk of side effects as well.

    David Emerson

    Reply
MGUS Nerve Pain - PeopleBeatingCancer says 8 years ago

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