Bladder Cancer and BCG- side effects and relapse?

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“Overall, our results suggest that curcumin potentiates the antitumor effect of BCG through the inhibition of NF-kappaB and induction of TRAIL receptors in bladder cancer cells…”

The link below is to a thread from an Inspire bladder cancer forum about a therapy called “BCG” (Bacillus Calmette-Guerin).

The thread or online conversation is about two of the most basic worries surrounding cancer therapy- side effects and the risk of relapse. I am posting this thread to provide info for anyone looking for basic information about BCG- information from bladder cancer survivors talking about their BCG therapy.

Image result for image of bladder cancer

According to the study linked and excerpted below “Up to 40% of patients with non-muscle-invasive bladder cancer (NMIBC) will fail intravesical bacillus Calmette-Guérin (BCG) therapy…” Further, according to the other study, curcumin both potentiates the efficacy of BCG as well as kills bladder cancer.

I am a cancer survivor and cancer coach. I have supplemented with Life Extension Super Bio-Curcumin for more than 10 years and I have remained in complete remission from my “incurable” cancer all that time.

Please scroll down, post a question or comment and I will reply to you ASAP.

Thank you,

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:


Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors.

“Overall, our results suggest that curcumin potentiates the antitumor effect of BCG through the inhibition of NF-kappaB and induction of TRAIL receptors in bladder cancer cells…”

The management of BCG failure in non-muscle-invasive bladder cancer: an update

“In this review, reasons explaining BCG failure, how to define BCG failure, optimal risk stratification and prediction of response and management of BCG failures are discussed…”

“I am starting BCG next week and am curious about the flu type side effects etc. and if people are unable to complete because of difficulties. I am an engineer so I love facts and statistics. I also am curious if many people have gone YEARS without reoccurance with High Grade cancer????”

45 replies    Reply

  • Oldest first

in the find it little box on the top right part of the page there is a lot of information. Type in BCG and you will get tons, but the simple answer is that not everyone get flu like symptoms, so do, some get worse. Some suffer from blood clots, some like me have no side effects.
It is hard to know about people who have gone years without recurrence, they usually drop off the board. if you read messages, they are usually newbies and people with metastatic cancer or people with RC issues.

i have written what i think are instructions for BCG…. check the find it box

..My diagnosis was T1..G2 with CIS in 2008.. I started the BCG maintenance protocolin 2009 my side effect were minimal compared to other ( flu like symtoms for a few days…aches .tiredness) and sometime it does get worse the more treatmennts you have..I had a reoccurance of a tumour in July 2011 resulting in an RC in Dec 2011…some people do go long than me ..but for some it does not work at all….good luck with your treatment

best wishes john..

Good morning. My RC was on 3/14/13. No side effects yet with the exception of infections. Best wishes to you on your journey. Bob
C270

I am starting BCG next week and am curious about the flu type side effects etc. and if people are unable to complete because of difficulties. I am an engineer so I love facts and statistics. I also am curious if many people have gone YEARS without reoccurance with High Grade cancer????

45 replies    Reply

in the find it little box on the top right part of the page there is a lot of information. Type in BCG and you will get tons, but the simple answer is that not everyone get flu like symptoms, so do, some get worse. Some suffer from blood clots, some like me have no side effects.
It is hard to know about people who have gone years without recurrence, they usually drop off the board. if you read messages, they are usually newbies and people with metastatic cancer or people with RC issues.

i have written what i think are instructions for BCG…. check the find it box

..My diagnosis was T1..G2 with CIS in 2008.. I started the BCG maintenance protocolin 2009 my side effect were minimal compared to other ( flu like symtoms for a few days…aches .tiredness) and sometime it does get worse the more treatmennts you have..I had a reoccurance of a tumour in July 2011 resulting in an RC in Dec 2011…some people do go long than me ..but for some it does not work at all….good luck with your treatment

best wishes john..

Good morning. My RC was on 3/14/13. No side effects yet with the exception of infections. Best wishes to you on your journey. Bob
C270

T1G3 diagnosis 16. Months ago and have gone through 15 BCG treatments. My side affects are chills, spasm’s, fatigue, and body aches. Side affect are lasting longer with each round. I also suffer from prolonged loss of appetite (weeks). At this point in my treatment, the side affects are worth dealing with…

Good luck and feel free to send me note if there are other topics you want to discuss.

I completed 6 treatments 6 weeks apart in June 2012. I went in September and was said to be a BCG failure. I had a reoccurrence. So I started BCG W/INF in November 2012. Completed 5 of the 6 (my original URO moved thus not finishing) and have been “clean and sober” since………..Starting maintenance BCG in May for 3 weeks………..

To view the entire thread, go to- https://www.inspire.com/groups/bladder-cancer-advocacy-network/discussion/bladder-cancer-recurrence-after-bcg-1/

Do you have bladder cancer? Have you undergone BCG therapy? What was your experience?

Thank you

David Emerson

 

 

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