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Cardiac Rehabilitation-Curcumin, Cardiovascular Disease, Heart Failure

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The p300-HAT inhibitory effects of curcumin have been demonstrated to ameliorate the development of cardiac hypertrophy and heart failure in animal models.

I developed a deep vein thrombosis (DVT) during chemotherapy in ’95, chronic atrial fibrillation (afib) in late 2010 and was told that I had chemotherapy-induced cardiomyopathy (heart failure) in early 2019. I am now both a long-term cancer survivor and a cardiac rehabilitation (CR) student.

I used to worry about my incurable cancer. Now I worry about my cardiovascular disease (CVD). I’ve learned that the basic philosophy of how I managed my incurable cancer is transferable to my cardiac rehabilitation efforts. I search for evidence-based, non-toxic, cardic rehabilitation therapies with the goal of healing my cardiovascular disease. These therapies include nutrition, supplementation, and lifestyle therapies, all documented to support heart health.

Curcumin is just such an evidence-based therapy.

According to the study linked an excerpted below, curcumin supplementation can:

  • attenuate adriamycin-induced cardiotoxicity
  • reduce my cholesterol
  • reduce my risk of DVT and stroke
  • helps dissolve my post-thrombotic syndrome

All is one inexpensive, non-toxic nutritional supplement. If it sounds as though curcumin is a wonder drug, it is. Curcumin also is cytotoxic (kills) to my cancer, multiple myeloma. I think it reduces my risk of Alzheimer disease but that’s another blog post.

All to say that if you have heart failure, high cholesterol, afib, PTS, please consider supplementing with curcumin. To learn more about this non-toxic wonder drug, scroll down the page, post a question or comment and I will reply to you ASAP.

Thank you,

David Emerson

  • Cardic Rehab Student
  • Cardiac Rehab Coach
  • Director Galen Foundation

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Cardiac rehabilitation

Cardiac rehabilitation (CR) is a branch of rehabilitation medicine or physical therapy dealing with optimizing physical function in patients with cardiac disease or recent cardiac surgeries. CR services can be provided during hospitalization for the event[1] or in an outpatient setting.[2] While the “glue” of cardiac rehabilitation is exercise, programs are evolving to become comprehensive prevention centers where all aspects of preventive cardiology care are delivered. This includes nutritional therapies, weight loss programs, management of lipid abnormalities with diet and medication, blood pressure control, diabetes management, and stress management…”

Cardiovascular disease

Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels.[2] CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack).[2] Other CVDs include stroke, heart failure, hypertensive heart disease, rheumatic heart disease, cardiomyopathy, heart arrhythmia, congenital heart disease, valvular heart disease, carditis, aortic aneurysms, peripheral artery disease, thromboembolic disease, and venous thrombosis.[2][3]

The protective role of curcumin in cardiovascular disease.

“Curcumin (diferuloylmethane) is a polyphenol responsible for the yellow color of the curry spice turmeric. It has been used in a variety of diseases in traditional medicine. Modern scientific research has demonstrated its anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-thrombotic, and cardiovascular protective effects.

In this review, we focused mainly on the effects of curcumin on the cardiovascular system. The antioxidant effects of curcumin have been shown to attenuate adriamycin-induced cardiotoxicity and may prevent diabetic cardiovascular complications.

The anti-thrombotic, anti-proliferative, and anti-inflammatory effects of curcumin and the effect of curcumin in decreasing the serum cholesterol level may protect against the pathological changes occurring with atherosclerosis.

The p300-HAT inhibitory effects of curcumin have been demonstrated to ameliorate the development of cardiac hypertrophy and heart failure in animal models. The inflammatory effects of curcumin may have the possibility of preventing atrial arrhythmias and the possible effect of curcumin for correcting the Ca(2+) homeostasis may play a role in the prevention of some ventricular arrhythmias. The preclinical studies from animal to clinical data in human are discussed.”

Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials

“Conclusions- Turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs. Further research is required to resolve uncertainties related to dosage form, dose and medication frequency of curcumin…”

Turmeric to Dissolve Blood Clots

“However, studies exist proving it will slow or inhibit formation of clots. This attribute, although useful in many cases, may also be associated with serious risks, so know the benefits versus the risks of consumption and how they apply to your health…

Turmeric’s Impact on Blood Clots-

A 1999 study in “Biochemical Pharmacology,” a 2005 study in the “Journal of Physiology and Pharmacology” and an ongoing study begun in 2009 by the USDA have shown that curcumin, a chemical in turmeric, reduces the risk of clogged arteries, strokes and heart attacks…

Potential role of curcumin in stroke prevention

“The cause for a majority of ischemic strokes can be attributed to an underlying atherosclerotic disease process. Longitudinal epidemiologic studies have associated several risk factors with the initiation and progression of symptomatic atherosclerosis including hypertension, diabetes mellitus and dyslipidemia, and it is estimated that optimal control of these factors could substantially reduce the occurrence of stroke [1]…

A promising single novel treatment that may simultaneously provide several vascular protective benefits for persons at risk for stroke is curcumin, which derives from the root of the plant Curcuma longa, and is regarded as the most biologically active constituent of the spice turmeric. Curcumin harbors several properties that could make it suitable for stroke prevention…”

 

 

 

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