“In what researchers said is the second study of its kind, it was determined that circulating vitamin D binding protein (DBP) is inversely associated with the risk of kidney cancer.1″
Whether you are trying to reduce your risk of getting kidney cancer or trying to reduce your risk of a kidney cancer relapse, increasing the amount of vitamin D3 in your blood can be a useful therapy. I am talking about a typical complementary therapy like nutrition, exercise or sleep. It is important to point out that your daily dose, either in a supplement or in liquid form, is not the best indicator of your blood levels.
I know this because I used to supplement what I thought was a therapeutic daily dose- 1,000 mg. When I got my blood levels checked, I learned that my blood levels were low- low being in the range of 10-20 ng/ml.
As you can read from the posts linked in the “Recommended Reading” section below, serum vitamin d3 can reduce the risk of several types of cancer, can reduce the risk of dementia and increase the health of your bones. Remarkable health benefit for an inexpensive, non-toxic supplement.
As you can see from the blog post linked above, my I try to keep blood levels of vitamin D3 between 30-40 ng/ml.
“In what researchers said is the second study of its kind, it was determined that circulating vitamin D binding protein (DBP) is inversely associated with the risk of kidney cancer.1 The findings, which were published in Cancer Epidemiology, Biomarkers & Prevention, support previous data that demonstrated that a higher DBP was linked to a decreased risk of developing renal cell carcinoma (RCC)….
The investigators found that a higher level of serum DBP concentration was inversely associated with renal cell carcinoma risk. Individuals with the highest levels of DBP were found to be younger, more likely to be female, had a lower BMI, and were more likely to be nonsmokers…
Alison Mondul, PhD, MSPH, assistant professor of epidemiology at the University of Michigan in Ann Arbor, and an author of the study, told Cancer Therapy Advisor that based on what is known so far, vitamin D itself doesn’t have a big effect on the risk of developing kidney cancer. But, DBP can help investigators estimate the proportion of vitamin D that is free versus bound in circulation. “Studies of other things in the body, like sex hormones, have suggested that only free, unbound hormones can have an effect. Based on a previous study, free vitamin D, just like total vitamin D, was also not associated with risk of RCC…”
Although previous studies have concluded that there was no strong link between circulating 15(OH)D and kidney cancer, and DBP did not appear to influence the risk association with 25(OH)D, the researchers hypothesized “that the biologic mechanism through which DBP influences risk of kidney cancer may be unrelated to its canonical role in vitamin D status and transport.”2 Simply put, DBP may influence carcinogenesis through a mechanism outside of its role of delivering vitamin D metabolites to various organs.
Limitations of the study included low statistical power to detect the effect of lifestyle factors and the bulk of cases examined were of patients with European ancestry. “Given that there is an existing racial disparity in kidney cancer incidence in the [United States] with higher rates among black men compared to white men, further study in non-white populations is warranted.”