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Grape Seed Extract-Reduce Mucositis & Enhance Colon Cancer Chemo

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Grape seed extract may represent a new therapeutic option to decrease the symptoms of intestinal mucositis (MU) while concurrently impacting on the viability of colon cancer cells

A diagnosis of colorectal cancer at stage 3 or 4 does not have a very good five-year survival rate. That is if you are only thinking conventionally. The standard-of-care for advanced colorectal cancer is surgery followed by aggressive chemotherapy.

mucositis picture showing redness, swelling, ulcer of mucus membrane

MU is a painful side effect that often accompanies toxic chemotherapy.

Dismal five year survival rates and painful collateral damage. If you could supplement with a non-toxic, evicence-based anti-oxidant to reduce chemo toxicity while enhancing chemo efficacy, would you? The study linked and excerpted below cites the ability of grape seed extract to reduce the severity of MU while enhancing the efficacy of chemotherapy.

For more information about reducing the risk of collateral damage and enhancing the efficacy of conventional chemotherapy, scroll down the page, post a question or comment and I will reply ASAP.

thank you,

David Emerson

  • Long-term Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

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“Mucositis is the painful inflammation and ulceration of the mucous membranes lining the digestive tract, usually as an adverse effect of chemotherapy and radiotherapy treatment for cancer.[1] Mucositis can occur anywhere along the gastrointestinal (GI) tract…”

Role of Vitamin E and Vitamin A in Oral Mucositis Induced by Cancer Chemo/Radiotherapy- A Meta-analysis

“Conclusion-Topical Vitamin E had performed better on oral MU than Vitamin E systemic administration. Though the efficacy of topical treatment with Vitamin A showed reduction in oral mucositis, it was evaluated in a very small sample which cannot be attributed to a larger sitting.

Dietary supplementation with omega-3 fatty acid attenuates 5-fluorouracil induced mucositis in mice

“Conclusion-Together, these results show that omega-3 fatty acid decreases the mucosal damage caused by 5-FU-induced MU…”

Adjunctive Treatments for the Prevention of Chemotherapy- and Radiotherapy-Induced Mucositis

Conclusion: There is plausible clinical evidence for the administration of several adjunctive treatments for the prevention and treatment of MU.

  • Probiotics were reported to reduce the burden of intestinal mucositis and treatment-induced diarrhea-
  • Activated charcoal and glutamine are beneficial for chemotherapy-induced diarrhea-
  • whereas the administration of honey, zinc, and glutamine reduce the risk of developing oral mucositis during chemotherapy or radiotherapy.

Grape Seed Extract Dose-Responsively Decreases Disease Severity in a Rat Model of Mucositis; Concomitantly Enhancing Chemotherapeutic Effectiveness in Colon Cancer Cells

Results-Compared with 5-Fluorouracil controls, grape seed extract (400–1000 mg/kg) significantly decreased the histological damage score (P<0.05) in the jejunum. Grape seed extract (1000 mg/kg) increased jejunal crypt depth by 25% (P<0.05) in 5-Fluorouracil treated rats compared to 5-Fluorouracil controls, and attenuated the 5-Fluorouracil -induced reduction of mucosal thickness (25%, P<0.05). Grape seed extract (600 mg/kg) decreased myeloperoxidase activity by 55% (P<0.01) compared to 5-Fluorouracil controls. Grape seed extract was more effective at ameliorating 5-Fluorouracil induced intestinal injury, with effects most pronounced in the proximal jejunum. Grape seed extract (10–25 ug/mL) significantly enhanced the growth-inhibitory effects of 5-Fluorouracil by 26% (P<0.05) in Caco-2 cells and was more potent than 5-Fluorouracil at 50–100 µg/mL.

Conclusion-Grape seed extract may represent a new therapeutic option to decrease the symptoms of intestinal MU while concurrently impacting on the viability of colon cancer cells.”

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7 comments
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Barbro Barklund says 7 years ago

How do you introduce grapeseed extract when you are on Warfarin? Nearly all veggies are out for me because of this and the ileostomy (all the tings I feel i need to be eating). Would also like to start on a product called Greens first, but Warfarin again is the problem.

Reply
    David Emerson says 7 years ago

    Hi Barbro- (great name btw)

    If I understand your post, you are trying to work through two issues? Both blood health as well as nutritional health? While both may affect your blood thinning and potential for DVT, etc. I think you should talk to either your onc. or perhaps a nutritionist that works with your onc. I am out of my depth when talking about nutritional supplementation (which I think is important) when combined with blood thinning drugs such as warfarin.

    I agree that veggies and nutritional supplementation such as GSE is an important part of one’s long term health so it is in your interest to figure out how to work with everything your mention in your post.

    I am sorry I can’t offer more specific information.

    Hang in there,

    David

    Reply
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