Green Tea Polyphenol (EGCG) and Pancreatic Cancer.

a couple of years ago
/ Pancreatic Cancer
/ By David Emerson
/ 9 COMMENTS

It shows that EGCG changes the metabolism of pancreatic cancer cells by suppressing the expression of lactate dehydrogenase A or LDHA

If you have been diagnosed with pancreatic cancer (PC) your first challenge is to deal with your oncologist telling you that little if anything can be done to fight pancreatic cancer. What he/she means is only that there is little that conventional oncology can offer as PC therapy.

As you can read from the articles linked and excerpted below, green tea (EGCG) kills PC. Further, there are several evidence-based antioxidants that have been shown to work synergistically with chemotherapy to also kill PC.

To take integrative and/or complementary therapies further, consider curcumin enhancing gemcitabine. Or ellagic acid also killing PC. My point is, PC patients must think outside the conventional chemo box.

Surgically removing the patient’s tumor is currently the only curative therapy for pancreatic cancer-
For PC patients with unresectable pancreatic cancer, consider radiation to reduce the PC in order to then surgically remove the tumor-
Consider integrative therapies- for example curcumin supplementation shown to enhance the efficacy of chemo

I am a long-term survivor of incurable cancer called multiple myeloma. Myeloma is incurable if the patient chooses to remain in the conventional oncology world. Like PC there are many evidence-based non-conventional therapies to pursue.

No, I am not offering a silver bullet. Make no mistake, PC is a complicated, difficult cancer to manage. All I am saying is that conventional oncology doesn’t offer much hope.

Please take a moment to watch the short video below in order to learn more about evidence-based therapies:

Have you been diagnosed with PC? Scroll down the page, post a question or comment and I will reply to you ASAP.

Thanks

David Emerson

Cancer Survivor
Cancer Coach
Director PeopleBeatingCancer

Prooxidative effects of green tea polyphenol (-)-epigallocatechin-3-gallate on the HIT-T15 pancreatic beta cell line.

“Epigallocatechin-3-gallate (EGCG) is the main polyphenolic constituent in green tea and is believed to function as an antioxidant. However, increasing evidence indicates that EGCG produces reactive oxygen species (ROS) and subsequent cell death. In this study, we investigated the prooxidative effects of EGCG on the HIT-T15 pancreatic beta cell line…

Treatment with EGCG (5-100 microM) decreased the viability of pancreatic beta cells, caused concomitant increases in apoptotic cell death, and increased the production of H(2)O(2) and ROS…

Together, these findings suggest that in the HIT-T15 pancreatic beta cell line, EGCG mediated the generation of H(2)O(2), triggering Fe(II)-dependent formation of a highly toxic radical that in turn induced oxidative cell damage.”

Green tea component upsets cancer cell metabolism

“Reported in the journal Metabolomics, the study explores the effect of epigallocatechin gallate or “EGCG,” an active biological agent of green tea. It shows that EGCG changes the metabolism of pancreatic cancer cells by suppressing the expression of lactate dehydrogenase A or LDHA, a critical enzyme in cancer metabolism…”

Therapeutic applications of curcumin for patients with pancreatic cancer

“A number of preclinical studies have demonstrated anticancer effects for curcumin in various types of tumors, including pancreatic cancer. Curcumin has anticancer effects both alone and in combination with other anticancer drugs (e.g., gemcitabine, 5-fluorouracil, and oxaliplatin), and it has been shown to modulate a variety of molecular targets in preclinical models, with more than 30 molecular targets identified to date.

Of these various molecules, NF-κB is thought to be one of the primary targets of curcumin activity. Based on these promising preclinical results, several research groups, including our own, have progressed to testing the anticancer effects of curcumin in clinical trials; however, the poor bioavailability of this agent has been the major challenge for its clinical application.

In this article, we review possible therapeutic applications of curcumin in patients with pancreatic cancer…”

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Green Tea Polyphenol (EGCG) and Pancreatic Cancer.

It shows that EGCG changes the metabolism of pancreatic cancer cells by suppressing the expression of lactate dehydrogenase A or LDHA

Recommended Reading:

Prooxidative effects of green tea polyphenol (-)-epigallocatechin-3-gallate on the HIT-T15 pancreatic beta cell line.

Green tea component upsets cancer cell metabolism

Therapeutic applications of curcumin for patients with pancreatic cancer

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