Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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You have been new diagnosed with multiple myeloma (MM). You have been told that your blood cancer is incurable. In the next breath your oncologist prescribes toxic chemotherapy regimens that will result in short, long-term and late stage side effects.
While I understand the need to undergo toxic therapies for manage multiple myeloma, I question the amount of toxicity proposed by the standard-of-care FDA approved “safe and effective” protocols.
Consider the supplementation of green tea and curcumin as evidence-based both complementary and integrative therapies.
According to the studies linked below show, both Green Tea extract and Curcumin are cytotoxic to (kill) multiple myeloma cells. Both green tea extract and curcumin enhance the efficacy of specific chemotherapy regimens.
My experience and research has shown that green tea extract is a remarkably effective non-conventional therapy for many reasons.
It is true that EGCG reduces the efficacy of Velcade (Bortezomib). If a MM patient is undergoing Velcade I will encourage that person to stop supplementing with green tea the day before his/her Velcade/bortezomib infusion and start again the day after the Velcade/bortezomib infusion.
I have been cancer-free from my cancer, multiple myeloma, considered to be “incurable” since 1999.
Consider a different scenario- you have been diagnosed with advanced multiple myeloma. It is clear to you that the conventional, FDA approved, standard-of-care therapies are not curative. Not only is the standard-of-care not curative, it probably entails nasty side effects.
I don’t mean to say that your prognosis is to live for 5-7 years, I mean that the conventional therapies are highly toxic, and, if you are honest with yourself, convey a good chance of NOT making it five years.
What do you do? Again, the studies below show that both green tea extract and curcumin enhance the efficacy of a number of conventional chemotherapies. Further both green tea extract and curcumin limit the toxicity of many conventional chemotherapies reducing possible side effects, reducing the damage you your body that comes with toxicity.
I am a long-term multiple myeloma survivor and MM cancer coach. To learn more about how non-toxic supplements can help you scroll down the page to post a question or comment and I will reply to you ASAP.
“The research within the last several years in vitro and in vivo (animal models) showed that curcumin can sensitize cancer cells to different chemotherapeutic agents that are commonly used for Multiple Myeloma treatment…
Preclinical studies on Curcumin and chemotherapeutic agents are expected to lead to clinical trials that will improve the treatment outcome for the patients with Multiple Myeloma…”
“Here, we demonstrate that EGCG, an antioxidant from green tea, induces growth arrest and apoptosis in MM cells while having no significant effect on normal PBMCs as well as fibroblasts.
Anticancer effects of EGCG have been demonstrated in vitro in several malignancies including human lung, cervical, colon, and oral squamous carcinoma cells with effective IC50 values ranging from 22 to 200 μM.14,18,31
However, this is the first report demonstrating its activity in hematologic malignancy and elucidating the molecular mechanisms of EGCG-induced apoptosis in cancer cells, specifically in MM. Exposure of myeloma cell lines and primary patient cells to 10 to 20 μM EGCG led to apoptotic cell death within 5 to 7 days…”
“However, our research team reviewed clinical trials on antioxidants that were given along with chemotherapy, and found there was little reason to suspect any interference with the effects of chemotherapy. In addition, researchers have found that polyphenols, such as EGCG, tend to become pro-oxidants when they are put into cancer cells. They then cause apoptosis, or cancer cell suicide, which actually reinforces the action of chemotherapy drugs. Therefore, we don’t believe that using green tea is problematic with most kinds of chemotherapy…”
“These data, therefore, indicate that a natural product with antioxidant properties from green tea has a specific activity against MM, making it an ideal compound for therapy and possible chemoprevention of this disease…”
In many ways, the ultimate multiple myeloma therapy is EGCG aka green tea. Let me explain. I’ve taken green tea extract for years. I was diagnosed with multiple myeloma in early 1994, achieved complete remission by 4/99 where I remain today.
Multiple myeloma (MM) patients and survivors must worry about:
Numerous studies document how many chemotherapy regimens cause DVT’s (blood clots) as well as damage to our hearts, both short and long-term. I have suffered from both of these MM side effects myself.
I was first diagnosed with multiple myeloma in 1994 and I still worry about my MM relapse as well as treatment related secondary cancers.
Aggressive chemotherapy and radiation didn’t do much to treat my MM it did cause all sorts of collateral damage aka short, long-term and late stage side effects including chronic a-fib, DVT and eventually chemotherapy-induced cardiomyopathy.
Which brings me to why I’m writing this post. I’ve been cancer-free since 1999. And though my chronic atrial fibrillation began in the fall of 2010 I haven’t had a stroke. I am doing well.
MM patients and survivors must think about the big picture more than survivors of other cancers- in my opinion anyway. While relapse is always on our mind, we should also think about our blood and heart health.
I have found that green tea extract is an effective therapy to address many of my possible health risks.
I supplement with green tea extract (GTE). The study linked and excerpted below is one of dozens of studies on PeopleBeatingCancer that support the consumption of evidence-based, non-conventional cancer therapies such as GTE to reduce the risks of all sorts of health challenges. I’ve been taking Life Extension Foundation’s Mega Green Tea for years.
I take Life Extension Mega Green Tea Extract because ConsumerLab.com has tested this supplement for purity, strength, and cost. and has assured me that LE Mega Green Tea is the best formulation for me.
“Here, we demonstrate that EGCG, an antioxidant from green tea, induces growth arrest and apoptosis in MM cells while having no significant effect on normal PBMCs as well as fibroblasts. Anticancer effects of EGCG have been demonstrated in vitro in several malignancies including human lung, cervical, colon, and oral squamous carcinoma cells…
Our data suggest higher susceptibility of MM cells to EGCG, which may provide a higher therapeutic index..
In conclusion, these studies demonstrate that EGCG is a potent suppressor of MM cell growth with specificity provided by its interaction with LR1, a cell-surface receptor implicated in the interaction of myeloma cells with basement membrane.
These data, therefore, indicate that a natural product with antioxidant properties from green tea has a specific activity against MM, making it an ideal compound for therapy and possible chemoprevention of this disease…”
“Objective To investigate the associations between GTE consumption and all-cause and cause-specific mortality.
Main Outcome Measures Mortality due to cardiovascular disease, cancer, and all causes.
Results Green tea consumption was inversely associated with mortality due to all causes and due to cardiovascular disease…
Among the types of cardiovascular disease mortality, the strongest inverse association was observed for stroke mortality. In contrast, the hazard ratios of cancer mortality were not significantly different from 1.00 in all green tea categories compared with the lowest-consumption category.
Conclusion GTE consumption is associated with reduced mortality due to all causes and due to cardiovascular disease but not with reduced mortality due to cancer.”
“Based on a review of these studies, it is evident that better bioavailability of formulated curcumin (CU) products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism”
A search of the Pubmed database for the word curcumin yields 601 studies spaning health topics from multiple myeloma and colorectal cancer, to chemotherapies that synergizes with CU, to Alzheimer’s Disease, arthritis and more. Based on years of reading studies and personal accounts, I think it is safe to say that CU supplementation is safe and relatively inexpensive.
I have read about myeloma patients taking daily doses of CU from 400 milligrams to 8 grams (1000 milligrams = 1 gram). By almost any measure, CU is a safe, inexpensive wonder drug.
The only challenge is that CU is famously difficult to absorb in the body. In other words, a person has to mix curcumin with some sort of fat (coconut oil, chocolate, etc.) or take a brand of curcumin capsule that is already formulated to be more “bioavailable” in order to derive the full benefit of CU.
The study linked and exerpted below reviews different formulations of CU. The study itself lists the three most bioavailable formulation/brand of CU and I’ve added an excerpt from a further review from Consumerlab.com that lists four additional bioavailable brands of CU.
“CU is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.“
“Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native CU is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability.
The purpose of this review is to collate the published clinical studies of CU products with improved bioavailability over conventional (unformulated) CU. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinetics data were included in this review. Further, the data on clinical study design, analytical method, pharmacokinetic parameters and other relevant details of each formulation were extracted.
Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations.
Based on the published reports,
exhibited over 100-fold higher bioavailability relative to reference unformulated CU. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed.”
According to Consumerlab.com:
“Novasol has the highest bioavailability (185 x compared to unforumulated CU), followed by Curcuwin (136 x), Longvida (100 x), Meriva (48 x), BCM-95 (27 x), Curcumin C3 Complex + Bioperene (20 x), and then Theracumin (16 x).”