MGUS & SMM Risk of Progression to Multiple Myeloma

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MGUS, SMM Risk of Progression is Where the Rubber Meets the Road!

Even if you have been diagnosed with either MGUS or SMM you may not have the diagnostic information about your pre-multiple myeloma to be able to determine your risk of progression to MM.

And even if you are able to determine your risk of progression to MM I believe that evidence-based, non-toxic therapies can reduce your risk of progression to MM. Please understand, I did everything my oncologist told me to do and I still relapsed and reached end-stage MM. Back in the fall of 1997. So I am cynical about conventional oncology. Especially where blood cancers are concerned.

Hi. My name is David Emerson. I am a long-term MM survivor and MM Cancer Coach. Welcome to PeopleBeatingCancer.org.

However, I do believe that having a thorough diagnosis and regular testing is critical for anyone diagnosed with pre-MM.

MGUS at a glance- click the illustration below:

MGUS png Mind Map

If you do not want to “watch and wait” to see if your MGUS/SMM progresses to Multiple Myeloma please watch the short video below:

Click here to get the FREE Pre-Myeloma Introduction Guide and follow along.

Click here to get the FREE Pre-Myeloma First Questions Guide.

Consider MGUS Therapies such as:

  1. non-toxic, cytotoxic/apoptotic supplements,
  2. foods that starve MGUS/SMM and MM
  3. evidence-based mind-body therapies,
  4. detoxification therapies,
  5. Non-conventional bone health therapies

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM): novel biological insights and development of early treatment strategies

“Predicting progression with current clinical risk models-

The Mayo Clinic risk stratification model for MGUS identifies 3 major risk factors for progression:

  • non-IgG isotype,
  • serum M-protein concentration > 1.5 g/dL, and
  • a skewed FLC-ratio (normal reference: 0.26-1.65).19

At 20 years of follow-up, absolute risk of progression for MGUS patients with 0, 1, 2, and 3 risk factors is

  • 5%,
  • 21%,
  • 37%, and
  • 58%, respectively (Table 2).19

For SMM, risk factors for progression include

  • bone marrow plasma cells > 10%,
  • serum M-protein concentration > 3 g/dL, and
  • a skewed FLC-ratio (normal reference: 0.125-8.0)

Cumulative risk of progression at 10 years for SMM patients with 1, 2, and 3 risk factors is:

  • 50%,
  • 65%, and
  • 84%, respectively (Table 2).20

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