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Diagnosed with SMM, SPB, or MGUS?

Learn how you can stall the development of full-blown Multiple Myeloma with evidence-based nutritional and supplementation therapies.

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MGUS- Lose Weight-Reduce Risk of Progression to Myeloma

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According to the study talked about in the video, curcumin and diet can slow the progression of Monoclonal Gammopathy of Undetermined Significance (MGUS) to Multiple Myeloma.

I don’t believe in diets. But I do believe that MGUS patients can change their lifestyle, lose weight and reduce their risk of progressing to Multiple Myeloma. Further, the same diet and lifestyle therapies have been shown to both starve multiple myeloma while also being cytotoxic to MM. Talk about a win-win.

MGUS at a glance- click the illustration below:

MGUS png Mind Map

Excess weigh causes inflammation. Inflammation is linked to cancer. The study below cites that overweight MGUS patients have almost twice the risk of MGUS becoming full blown multiple myeloma.

I didn’t try to but I have lost about 20 pounds over the past 20 years by living an evidence-based, non-toxic, anti-MM lifestyle that has keep me in complete remission from my MM since 4/99.

The question is, can Monoclonal Gammopathy of Undetermined Significance patients reduce or eliminate his/her risk of their pre-MM progressing to MM? Yes, according to the short video linked below. According to the study talked about in the video, curcumin and diet can slow the progression of pre-MM to MM. In addition there are evidence-based therapies that act like curcumin does as an anti-oxidant, anti-inflammatory, etc. supplement.

I am both a long-term MM survivor and MM cancer coach. I have lived in complete remission from my multiple myeloma since 1999 by living an evidence-based, non-toxic, anti-MM lifestyle.

To learn more about the evidence-based protocols you can follow to prevent your Pre-Myeloma from becoming Multiple Myeloma, please watch the short video below:

 

If you do not want to “watch and wait” to see if your Monoclonal Gammopathy of Undetermined Significance progresses to Multiple Myeloma scroll down the page, post a question or a comment and I will reply to you ASAP.

Consider evidence-based, non-toxic therapies such as:

  1. non-toxic, cytotoxic/apoptotic supplements,
  2. foods that starve MGUS
  3. evidence-based mind-body therapies,
  4. detoxification therapies,
  5. bone health therapies

Thanks and hang in there,

David Emerson
  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Turmeric Curcumin, MGUS, and Multiple Myeloma

Monoclonal Gammopathy of Undetermined Significance may progress to multiple myeloma, AL amyloidosis, Waldenstrom’s macroglobulinemia, or lymphoma. But not all cases progress to malignancy.

Obesity Increases Risk for Transformation of MGUS to Multiple Myeloma

“Obesity and black race are associated with an increased risk for transformation of monoclonal gammopathy of undetermined significance to MM…

During a median follow-up of 68 months, 329 (4.2%) patients with Monoclonal Gammopathy of Undetermined Significance progressed to MM, including 72 (3.5%) normal-weight patients, 144 (4.6%) overweight patients, and 113 (4.3%) obese patients.

After adjusting for multiple variables, researchers found that obese patients had a nearly 2 times higher risk for progressing to MM than normal-weight patients…”

The Most BioAvailable Curcumin Formulas

“Based on a review of these studies, it is evident that better bioavailability of formulated curcumin (CU) products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism”

A search of the Pubmed database for the word curcumin yields 601 studies spaning health topics from multiple myeloma and colorectal cancer, to chemotherapies that synergizes with CU, to Alzheimer’s Disease, arthritis and more. Based on years of reading studies and personal accounts, I think it is safe to say that CU supplementation is safe and relatively inexpensive.

I have read about myeloma patients taking daily doses of CU from 400 milligrams to 8 grams (1000 milligrams = 1 gram). By almost any measure, CU is a safe, inexpensive wonder drug.

The only challenge is that CU is famously difficult to absorb in the body. In other words, a person has to mix curcumin with some sort of fat (coconut oil, chocolate, etc.) or take a brand of curcumin capsule that is already formulated to be more “bioavailable” in order to derive the full benefit of CU.

The study linked and exerpted below reviews different formulations of CU. The study itself lists the three most bioavailable formulation/brand of CU and I’ve added an excerpt from a further review from Consumerlab.com that lists four additional bioavailable brands of CU.

Recommended Reading:

Curcumin

“CU is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.[1]“

Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers.

“Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native CU is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability.

The purpose of this review is to collate the published clinical studies of CU products with improved bioavailability over conventional (unformulated) CU. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinetics data were included in this review. Further, the data on clinical study design, analytical method, pharmacokinetic parameters and other relevant details of each formulation were extracted.

Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations.

Based on the published reports,

exhibited over 100-fold higher bioavailability relative to reference unformulated CU. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed.”

According to Consumerlab.com:

“Novasol has the highest bioavailability (185 x compared to unforumulated CU), followed by Curcuwin (136 x), Longvida (100 x), Meriva (48 x), BCM-95 (27 x), Curcumin C3 Complex + Bioperene (20 x), and then Theracumin (16 x).”

Leave a Comment:

26 comments
Whole-Body Hyperthermia - Smoldering Myeloma... - PeopleBeatingCancer says last year

[…] MGUS- Lose Weight-Reduce Risk of Progression to Myeloma […]

Reply
MGUS Diagnosis - PeopleBeatingCancer says last year

[…] MGUS- Lose Weight-Reduce Risk of Progression to Myeloma […]

Reply
Angeline mueni says a couple of years ago

Am Angela m band found in gamma region am stressed my doctor has not interested yet feel so low please help

Reply
Rice Bran (MGN-3), Curcumin Kill MGUS, SMM- PeopleBeatingCancer says 3 years ago

[…] MGUS- Lose Weight-Reduce Risk of Progression to Myeloma […]

Reply
Gloria Papillon says 3 years ago

I just slipped over from mgus to phase 1 mm. Can I hope to reverse or stay the same following your program?

Reply
    David Emerson says 3 years ago

    Hi Gloria-

    I will reply to both your questions via an email sent to your email address.

    thanks,

    David

    Reply
Monoclonal Gammopathy of Undetermined Significance (MGUS) Explained - PeopleBeatingCancer says 5 years ago

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Lee Coulson-Day says 6 years ago

Hi I was diagnosed having MGUS in 2015, and from internet information devastated. A middle aged father of six children, loving marriage, and to be honest had only just started living after many years haunted by past abuse, violent circumstances, and injury. I recently passed a LAw BSc degree with honours, work at an organic farm, and starting to be able to enjoy my life. The blow was terrible for my wife and I, especially as we were given no other information from our GP than ‘Well… we all got to die of something… Right!’ Since I have learned that it is quite a low strain, but last time I went for a blood test it had risen by 0.5… I was under some stress because one of my sons, but like all I suspect trying to find ways of slowing the process, even reversing it. I have been looking at the work of Dr Ernest Rossi, and that of Dr J Dispenza, who use psychobiological methods to try and promote change at both
psychological and cellular levels. But any information I can get to help would be wonderful.

Reply
    David Emerson says 6 years ago

    Hi Lee-

    I am sorry to read of your MGUS diagnosis. However I developed the MGUS cancer coaching program specifically because many pre-MM people do not want to either “watch and wait” and cannot accept their GP telling them that we all have to die sometime. Yes, there are documented cases of pre-MM (SBP, MGUS and SMM) of regressing to normal blood levels and/or remaining in a pre-MM state for decades.

    Please keep in mind that MGUS is referred to as either a “blood disorder” or pre-MM but it is not cancer. Yes, it can lead to cancer but it does not always.

    An m-spike of .05 is quite low. The non-toxic therapies discussed in the pre-MM CC program are all evidence-based. I include links to studies supporting therapies such as curcumin. And I am happy to discuss specific formulations that are more bioavailable, specific doses, etc.

    Let me know if you have any questions.

    Hang in there,

    David Emerson

    Reply
      Charles Fisher says 5 years ago

      Very interested in the Curcumin regiment. Resently diag with MGUS. Amounts and brand and any other dietary info. Thanks

      Reply
        David Emerson says 5 years ago

        Hi Charles-

        I am sorry to learn of your MGUS diagnosis but glad to read that you are undergoing therapies to reduce your risk of frank MM. Regarding your question about curcumin, several things. I will post an article that talks and lists the most “bioavailable” curcumin formulas. My curcumin brand, Life Extension SuperBio Curcumin is enhanced (7x I think) but is not one of the top brands. Further, I read of those with active MM or pre-MM, dosing at levels of 1,2,8 grams- (1000 mgs is 1 gram) I take one capsule that is 400 mgs.

        This is for you to decide- The Pre-MM Cancer Coaching Program expands on evidence-based non-toxic therapies like curcumin.

        The Most BioAvailable Curcumin Formulas

        Let me know if you have any other questions.

        David Emerson

        Reply
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